An informatics research agenda to support precision medicine: Seven key areas

Jessica D. Tenenbaum, Paul Avillach, Marge Benham-Hutchins, Matthew K. Breitenstein, Erin L. Crowgey, Mark A. Hoffman, Xia Jiang, Subha Madhavan, John E. Mattison, Radhakrishnan Nagarajan, Bisakha Ray, Dmitriy Shin, Shyam Visweswaran, Zhongming Zhao, Robert R. Freimuth

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


The recent announcement of the Precision Medicine Initiative by President Obama has brought precision medicine (PM) to the forefront for healthcare providers, researchers, regulators, innovators, and funders alike. As technologies continue to evolve and datasets grow in magnitude, a strong computational infrastructure will be essential to realize PM's vision of improved healthcare derived from personal data. In addition, informatics research and innovation affords a tremendous opportunity to drive the science underlying PM. The informatics community must lead the development of technologies and methodologies that will increase the discovery and application of biomedical knowledge through close collaboration between researchers, clinicians, and patients. This perspective highlights seven key areas that are in need of further informatics research and innovation to support the realization of PM.

Original languageEnglish (US)
Pages (from-to)791-795
Number of pages5
JournalJournal of the American Medical Informatics Association
Issue number4
StatePublished - Jul 2016


  • Biomarkers
  • Data sharing
  • Informatics
  • Precision medicine

ASJC Scopus subject areas

  • Health Informatics


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