An ex vivo technique for quantifying mouse lung injury using ultrasound surface wave elastography

Boran Zhou; Kyle J. Schaefbauer; Ashley M. Egan; Eva M. Carmona Porquera; Andrew H. Limper; Xiaoming Zhang

doi:10.1016/j.jbiomech.2019.109468

An ex vivo technique for quantifying mouse lung injury using ultrasound surface wave elastography

Boran Zhou, Kyle J. Schaefbauer, Ashley M. Egan, Eva M. Carmona Porquera, Andrew H. Limper, Xiaoming Zhang

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Idiopathic pulmonary fibrosis is a progressively fatal disease with limited treatments. The bleomycin mouse model is often used to simulate the disease process in laboratory studies. The aim of this study was to develop an ex vivo technique for assessing mice lung injury using lung ultrasound surface wave elastography (LUSWE) in the bleomycin mouse model. The surface wave speeds were measured at three frequencies of 100, 200, and 300 Hz for mice lungs from control, mild, and severe groups. The results showed significant differences in the lung surface wave speeds, pulse oximetry, and compliance between control mice and mice with severe pulmonary fibrosis. LUSWE is an evolving technique for evaluating lung stiffness and may be useful for assessing pulmonary fibrosis in the bleomycin mouse model.

Original language	English (US)
Article number	109468
Journal	Journal of Biomechanics
Volume	98
DOIs	https://doi.org/10.1016/j.jbiomech.2019.109468
State	Published - Jan 2 2020

Keywords

Bleomycin (BLM)
Idiopathic pulmonary fibrosis (IPF)
Lung ultrasound surface wave elastography (LUSWE)
Mice
Surface wave speed

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Orthopedics and Sports Medicine
Rehabilitation

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10.1016/j.jbiomech.2019.109468

Cite this

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title = "An ex vivo technique for quantifying mouse lung injury using ultrasound surface wave elastography",

abstract = "Idiopathic pulmonary fibrosis is a progressively fatal disease with limited treatments. The bleomycin mouse model is often used to simulate the disease process in laboratory studies. The aim of this study was to develop an ex vivo technique for assessing mice lung injury using lung ultrasound surface wave elastography (LUSWE) in the bleomycin mouse model. The surface wave speeds were measured at three frequencies of 100, 200, and 300 Hz for mice lungs from control, mild, and severe groups. The results showed significant differences in the lung surface wave speeds, pulse oximetry, and compliance between control mice and mice with severe pulmonary fibrosis. LUSWE is an evolving technique for evaluating lung stiffness and may be useful for assessing pulmonary fibrosis in the bleomycin mouse model.",

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author = "Boran Zhou and Schaefbauer, {Kyle J.} and Egan, {Ashley M.} and {Carmona Porquera}, {Eva M.} and Limper, {Andrew H.} and Xiaoming Zhang",

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AU - Schaefbauer, Kyle J.

AU - Egan, Ashley M.

AU - Carmona Porquera, Eva M.

AU - Limper, Andrew H.

AU - Zhang, Xiaoming

PY - 2020/1/2

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AB - Idiopathic pulmonary fibrosis is a progressively fatal disease with limited treatments. The bleomycin mouse model is often used to simulate the disease process in laboratory studies. The aim of this study was to develop an ex vivo technique for assessing mice lung injury using lung ultrasound surface wave elastography (LUSWE) in the bleomycin mouse model. The surface wave speeds were measured at three frequencies of 100, 200, and 300 Hz for mice lungs from control, mild, and severe groups. The results showed significant differences in the lung surface wave speeds, pulse oximetry, and compliance between control mice and mice with severe pulmonary fibrosis. LUSWE is an evolving technique for evaluating lung stiffness and may be useful for assessing pulmonary fibrosis in the bleomycin mouse model.

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KW - Idiopathic pulmonary fibrosis (IPF)

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KW - Surface wave speed

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An ex vivo technique for quantifying mouse lung injury using ultrasound surface wave elastography

Abstract

Keywords

ASJC Scopus subject areas

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