TY - JOUR
T1 - Amyloidosis
AU - Gertz, M. A.
AU - Lacy, M. Q.
AU - Dispenzieri, A.
N1 - Funding Information:
Supported in part by the Quade Amyloidosis Research Fund.
PY - 1999
Y1 - 1999
N2 - Amyloidosis is considered rare but has an incidence similar to that of Hodgkin's disease and chronic granulocytic leukemia. The diagnosis should be considered in any patient with unexplained nephrotic-range proteinuria, heart failure, peripheral neruopathy, or hepatomegaly. If a monoclonal protein is found in a patient with any of these clinical presentations, a biopsy should be performed and the specimen stained with Congo red. The simplest source of diagnostic material is subcutaneous fat tissue. Treatment usually consists of chemotherapy, which may be oral and low dose or high dose with stem cell rescue.
AB - Amyloidosis is considered rare but has an incidence similar to that of Hodgkin's disease and chronic granulocytic leukemia. The diagnosis should be considered in any patient with unexplained nephrotic-range proteinuria, heart failure, peripheral neruopathy, or hepatomegaly. If a monoclonal protein is found in a patient with any of these clinical presentations, a biopsy should be performed and the specimen stained with Congo red. The simplest source of diagnostic material is subcutaneous fat tissue. Treatment usually consists of chemotherapy, which may be oral and low dose or high dose with stem cell rescue.
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U2 - 10.1016/S0889-8588(05)70122-2
DO - 10.1016/S0889-8588(05)70122-2
M3 - Article
C2 - 10626146
AN - SCOPUS:0033384860
SN - 0889-8588
VL - 13
SP - 1211
EP - 1233
JO - Hematology/Oncology Clinics of North America
JF - Hematology/Oncology Clinics of North America
IS - 6
ER -