Amyloid-like Fibronectin Deposits in the Liver: A Novel Morphologic Finding

Saba Yasir, Karen L. Rech, Zongming Eric Chen, Michael S. Torbenson

Research output: Contribution to journalArticlepeer-review


Amyloid deposits in the liver are recognized by their hematoxylin and eosin (H&E) findings, consisting of acellular eosinophilic deposits in various compartments of the liver parenchyma, including the stroma, vessels, and rarely the hepatocytes. H&E findings that suggest amyloid are then confirmed by Congo red stains and subtyped when clinically needed. Two cases are reported with sinusoidal deposits of acellular material that closely mimicked amyloid on H&E, but were Congo red negative. Mass spectrometry-based proteomic analysis identified the material as fibronectin. In 1 case, the deposits were located in the sinusoids of a well-differentiated hepatocellular carcinoma and in 1 case in the sinusoids of a benign liver.

Original languageEnglish (US)
Pages (from-to)205-208
Number of pages4
JournalAmerican Journal of Surgical Pathology
Issue number2
StatePublished - Feb 2021


  • Congo red
  • amyloid
  • fibronectin
  • mass spectrometry

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine


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