Aluminum Contamination of Albumin-Replacement Solutions

E. A. Loeliger, F. A. de Wolff, Dawn S. Milliner, Fred Feldman, James H. Shinaberger, Jack W. Coburn

Research output: Contribution to journalLetterpeer-review

14 Scopus citations


To the Editor: Milliner et al. (Jan. 17 issue)1 were unable to explain why commercially available albumin solutions contain large quantities of aluminum. They concluded, however, that it must be an artifact of collection, processing, or storage. We think that an observation of ours, made 15 years ago, may elucidate their observation. For decades aluminum hydroxide [Al(OH)3] gel has been used in the coagulation laboratory to absorb the vitamin K–dependent coagulation factors. By means of this principle, concentrates of the four factors can be obtained for use in clinical practice.2 However, the aluminum compound is not easily removed.

Original languageEnglish (US)
Pages (from-to)1389-1390
Number of pages2
JournalNew England Journal of Medicine
Issue number21
StatePublished - May 23 1985

ASJC Scopus subject areas

  • General Medicine


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