Alterations in pulmonary vasomotor modulators post aerobic exercise training in non-alcoholic fatty liver disease

Jinkyung Cho; Bruce D. Johnson; Kymberly D. Watt; Alexander S. Niven; Junchul Shin; Chul Ho Kim

doi:10.1016/j.resp.2023.104089

Alterations in pulmonary vasomotor modulators post aerobic exercise training in non-alcoholic fatty liver disease

Jinkyung Cho, Bruce D. Johnson, Kymberly D. Watt, Alexander S. Niven, Junchul Shin, Chul Ho Kim

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigated the impact of exercise training on major pulmonary vasomotor mediators and receptors including endothelial nitric oxide synthase (eNOS) inducible NOS (iNOS), endothelin-1 (ET-1), ET-1 receptors A (ET_A) and-B (ET_B) in high-fat-high-carbohydrate (HFHC) induced non-alcoholic fatty liver disease (NAFLD). NAFLD increased iNOS, ET-1 and ET_A (p < 0.05)_, but not ET_B (p > 0.05). Exercise attenuated iNOS, ET-1 and ET_A (p < 0.05)_., but not ET_B (p > 0.05) and eNOS (p > 0.05). Exercise training is beneficial for pulmonary vasculature in NAFLD.

Original language	English (US)
Article number	104089
Journal	Respiratory Physiology and Neurobiology
Volume	314
DOIs	https://doi.org/10.1016/j.resp.2023.104089
State	Published - Aug 2023

Keywords

ENOS
ET-1
Exercise
INOS
NAFLD
Pulmonary

ASJC Scopus subject areas

General Neuroscience
Physiology
Pulmonary and Respiratory Medicine

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10.1016/j.resp.2023.104089

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title = "Alterations in pulmonary vasomotor modulators post aerobic exercise training in non-alcoholic fatty liver disease",

abstract = "This study investigated the impact of exercise training on major pulmonary vasomotor mediators and receptors including endothelial nitric oxide synthase (eNOS) inducible NOS (iNOS), endothelin-1 (ET-1), ET-1 receptors A (ETA) and-B (ETB) in high-fat-high-carbohydrate (HFHC) induced non-alcoholic fatty liver disease (NAFLD). NAFLD increased iNOS, ET-1 and ETA (p < 0.05), but not ETB (p > 0.05). Exercise attenuated iNOS, ET-1 and ETA (p < 0.05)., but not ETB (p > 0.05) and eNOS (p > 0.05). Exercise training is beneficial for pulmonary vasculature in NAFLD.",

keywords = "ENOS, ET-1, Exercise, INOS, NAFLD, Pulmonary",

author = "Jinkyung Cho and Johnson, {Bruce D.} and Watt, {Kymberly D.} and Niven, {Alexander S.} and Junchul Shin and Kim, {Chul Ho}",

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year = "2023",

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doi = "10.1016/j.resp.2023.104089",

language = "English (US)",

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AU - Cho, Jinkyung

AU - Johnson, Bruce D.

AU - Watt, Kymberly D.

AU - Niven, Alexander S.

AU - Shin, Junchul

AU - Kim, Chul Ho

PY - 2023/8

Y1 - 2023/8

N2 - This study investigated the impact of exercise training on major pulmonary vasomotor mediators and receptors including endothelial nitric oxide synthase (eNOS) inducible NOS (iNOS), endothelin-1 (ET-1), ET-1 receptors A (ETA) and-B (ETB) in high-fat-high-carbohydrate (HFHC) induced non-alcoholic fatty liver disease (NAFLD). NAFLD increased iNOS, ET-1 and ETA (p < 0.05), but not ETB (p > 0.05). Exercise attenuated iNOS, ET-1 and ETA (p < 0.05)., but not ETB (p > 0.05) and eNOS (p > 0.05). Exercise training is beneficial for pulmonary vasculature in NAFLD.

AB - This study investigated the impact of exercise training on major pulmonary vasomotor mediators and receptors including endothelial nitric oxide synthase (eNOS) inducible NOS (iNOS), endothelin-1 (ET-1), ET-1 receptors A (ETA) and-B (ETB) in high-fat-high-carbohydrate (HFHC) induced non-alcoholic fatty liver disease (NAFLD). NAFLD increased iNOS, ET-1 and ETA (p < 0.05), but not ETB (p > 0.05). Exercise attenuated iNOS, ET-1 and ETA (p < 0.05)., but not ETB (p > 0.05) and eNOS (p > 0.05). Exercise training is beneficial for pulmonary vasculature in NAFLD.

KW - ENOS

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KW - Exercise

KW - INOS

KW - NAFLD

KW - Pulmonary

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ER -

Alterations in pulmonary vasomotor modulators post aerobic exercise training in non-alcoholic fatty liver disease

Abstract

Keywords

ASJC Scopus subject areas

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