Alcohol and nicotine administration inhibits serotonin synthesis and tryptophan hydroxylase expression in dorsal and median raphe of young rats

Mi Hyeon Jang; Min Chul Shin; Taeck Hyun Lee; Young Pyo Kim; Sae Bin Jung; Dong Hoon Shin; Hong Kim; Sung Soo Kim; Ee Hwa Kim; Chang Ju Kim

doi:10.1016/S0304-3940(02)00622-5

Alcohol and nicotine administration inhibits serotonin synthesis and tryptophan hydroxylase expression in dorsal and median raphe of young rats

Mi Hyeon Jang, Min Chul Shin, Taeck Hyun Lee, Young Pyo Kim, Sae Bin Jung, Dong Hoon Shin, Hong Kim, Sung Soo Kim, Ee Hwa Kim, Chang Ju Kim

Neurosurgery

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22 Scopus citations

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of various neuropsychiatric disorders. In the present study, the effects of alcohol and nicotine on the synthesis of 5-HT and the expression of tryptophan hydroxylase (TPH), the rate-limiting enzyme of 5-HT synthesis, in the dorsal and median raphe of young rats were investigated via immunohistochemistry. The numbers of the 5-HT-positive and TPH-positive cells were reduced by alcohol and nicotine treatment in a dose-dependent manner. Based on the results, it can be suggested that the pathogenesis of alcohol- and nicotine-induced neuropsychological disorders involves alcohol- and nicotine-induced suppression of 5-HT synthesis and TPH expression in raphe, and that this may be of particular relevance in the consumption of alcohol and nicotine during adolescence.

Original language	English (US)
Pages (from-to)	141-144
Number of pages	4
Journal	Neuroscience Letters
Volume	329
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(02)00622-5
State	Published - Aug 30 2002

Keywords

Adolescence
Alcohol
Nicotine
Raphe nuclei
Serotonin
Tryptophan hydroxylase

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(02)00622-5

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title = "Alcohol and nicotine administration inhibits serotonin synthesis and tryptophan hydroxylase expression in dorsal and median raphe of young rats",

abstract = "Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of various neuropsychiatric disorders. In the present study, the effects of alcohol and nicotine on the synthesis of 5-HT and the expression of tryptophan hydroxylase (TPH), the rate-limiting enzyme of 5-HT synthesis, in the dorsal and median raphe of young rats were investigated via immunohistochemistry. The numbers of the 5-HT-positive and TPH-positive cells were reduced by alcohol and nicotine treatment in a dose-dependent manner. Based on the results, it can be suggested that the pathogenesis of alcohol- and nicotine-induced neuropsychological disorders involves alcohol- and nicotine-induced suppression of 5-HT synthesis and TPH expression in raphe, and that this may be of particular relevance in the consumption of alcohol and nicotine during adolescence.",

keywords = "Adolescence, Alcohol, Nicotine, Raphe nuclei, Serotonin, Tryptophan hydroxylase",

author = "Jang, {Mi Hyeon} and Shin, {Min Chul} and Lee, {Taeck Hyun} and Kim, {Young Pyo} and Jung, {Sae Bin} and Shin, {Dong Hoon} and Hong Kim and Kim, {Sung Soo} and Kim, {Ee Hwa} and Kim, {Chang Ju}",

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doi = "10.1016/S0304-3940(02)00622-5",

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T1 - Alcohol and nicotine administration inhibits serotonin synthesis and tryptophan hydroxylase expression in dorsal and median raphe of young rats

AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Lee, Taeck Hyun

AU - Kim, Young Pyo

AU - Jung, Sae Bin

AU - Shin, Dong Hoon

AU - Kim, Hong

AU - Kim, Sung Soo

AU - Kim, Ee Hwa

AU - Kim, Chang Ju

PY - 2002/8/30

Y1 - 2002/8/30

N2 - Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of various neuropsychiatric disorders. In the present study, the effects of alcohol and nicotine on the synthesis of 5-HT and the expression of tryptophan hydroxylase (TPH), the rate-limiting enzyme of 5-HT synthesis, in the dorsal and median raphe of young rats were investigated via immunohistochemistry. The numbers of the 5-HT-positive and TPH-positive cells were reduced by alcohol and nicotine treatment in a dose-dependent manner. Based on the results, it can be suggested that the pathogenesis of alcohol- and nicotine-induced neuropsychological disorders involves alcohol- and nicotine-induced suppression of 5-HT synthesis and TPH expression in raphe, and that this may be of particular relevance in the consumption of alcohol and nicotine during adolescence.

AB - Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of various neuropsychiatric disorders. In the present study, the effects of alcohol and nicotine on the synthesis of 5-HT and the expression of tryptophan hydroxylase (TPH), the rate-limiting enzyme of 5-HT synthesis, in the dorsal and median raphe of young rats were investigated via immunohistochemistry. The numbers of the 5-HT-positive and TPH-positive cells were reduced by alcohol and nicotine treatment in a dose-dependent manner. Based on the results, it can be suggested that the pathogenesis of alcohol- and nicotine-induced neuropsychological disorders involves alcohol- and nicotine-induced suppression of 5-HT synthesis and TPH expression in raphe, and that this may be of particular relevance in the consumption of alcohol and nicotine during adolescence.

KW - Adolescence

KW - Alcohol

KW - Nicotine

KW - Raphe nuclei

KW - Serotonin

KW - Tryptophan hydroxylase

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AN - SCOPUS:0037199655

SN - 0304-3940

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JO - Neuroscience Letters

JF - Neuroscience Letters

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ER -

Alcohol and nicotine administration inhibits serotonin synthesis and tryptophan hydroxylase expression in dorsal and median raphe of young rats

Abstract

Keywords

ASJC Scopus subject areas

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