TY - JOUR
T1 - Alarmins at the maternal–fetal interface
T2 - Involvement of inflammation in placental dysfunction and pregnancy complications1
AU - Brien, Marie Eve
AU - Baker, Bernadette
AU - Duval, Cyntia
AU - Gaudreault, Virginie
AU - Jones, Rebecca L.
AU - Girard, Sylvie
N1 - Publisher Copyright:
© 2019, Published by NRC Research Press.
PY - 2019
Y1 - 2019
N2 - Inflammation is known to be associated with placental dysfunction and pregnancy complications. Infections are well known to be a cause of inflammation but they are frequently undetectable in pregnancy complications. More recently, the focus has been extended to inflammation of noninfectious origin, namely caused by endogenous mediators known as “damage-associated molecular patterns (DAMPs)” or alarmins. In this manuscript, we review the mechanism by which inflammation, sterile or infectious, can alter the placenta and its function. We discuss some classical DAMPs, such as uric acid, high mobility group box 1 (HMGB1), cell-free fetal deoxyribonucleic acid (DNA) (cffDNA), S100 proteins, heat shock protein 70 (HSP70), and adenosine triphosphate (ATP) and their impact on the placenta. We focus on the main placental cells (i.e., trophoblast and Hofbauer cells) and describe the placental response to, and release of, DAMPs. We also covered the current state of knowledge about the role of DAMPs in pregnancy complications including preeclampsia, fetal growth restriction, preterm birth, and stillbirth and possible therapeutic strategies to preserve placental function.
AB - Inflammation is known to be associated with placental dysfunction and pregnancy complications. Infections are well known to be a cause of inflammation but they are frequently undetectable in pregnancy complications. More recently, the focus has been extended to inflammation of noninfectious origin, namely caused by endogenous mediators known as “damage-associated molecular patterns (DAMPs)” or alarmins. In this manuscript, we review the mechanism by which inflammation, sterile or infectious, can alter the placenta and its function. We discuss some classical DAMPs, such as uric acid, high mobility group box 1 (HMGB1), cell-free fetal deoxyribonucleic acid (DNA) (cffDNA), S100 proteins, heat shock protein 70 (HSP70), and adenosine triphosphate (ATP) and their impact on the placenta. We focus on the main placental cells (i.e., trophoblast and Hofbauer cells) and describe the placental response to, and release of, DAMPs. We also covered the current state of knowledge about the role of DAMPs in pregnancy complications including preeclampsia, fetal growth restriction, preterm birth, and stillbirth and possible therapeutic strategies to preserve placental function.
KW - Alarmins
KW - DAMPs
KW - HMGB1
KW - Hofbauer cell
KW - Infection
KW - Inflammation
KW - Lipopolysaccharides
KW - Placenta
KW - Sterile inflammation
KW - Trophoblast
KW - Uric acid
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UR - http://www.scopus.com/inward/citedby.url?scp=85062402268&partnerID=8YFLogxK
U2 - 10.1139/cjpp-2018-0363
DO - 10.1139/cjpp-2018-0363
M3 - Review article
C2 - 30485131
AN - SCOPUS:85062402268
SN - 0008-4212
VL - 97
SP - 206
EP - 212
JO - Canadian Journal of Physiology and Pharmacology
JF - Canadian Journal of Physiology and Pharmacology
IS - 3
ER -