Aging-Related Mechanisms Contribute to Corticosteroid Insensitivity in Elderly Asthma

Maria L. Ford, Anushka Ruwanpathirana, Brandon W. Lewis, Rodney D. Britt

Research output: Contribution to journalReview articlepeer-review


Asthma in elderly populations is an increasing health problem that is accompanied by diminished lung function and frequent exacerbations. As potent anti-inflammatory drugs, corticosteroids are commonly used to reduce lung inflammation, improve lung function, and manage disease symptoms in asthma. Although effective for most individuals, older patients are more insensitive to corticosteroids, making it difficult to manage asthma in this population. With the number of individuals older than 65 continuing to increase, it is important to understand the distinct mechanisms that promote corticosteroid insensitivity in the aging lung. In this review, we discuss corticosteroid insensitivity in asthma with an emphasis on mechanisms that contribute to persistent inflammation and diminished lung function in older individuals.

Original languageEnglish (US)
Article number6347
JournalInternational journal of molecular sciences
Issue number7
StatePublished - Apr 2023


  • aging
  • airway inflammation
  • asthma
  • corticosteroid insensitivity
  • senescence

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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