Aging-related adaptations in the corticotropic axis: Modulation by gender

Johannes D. Veldhuis, Daniel M. Keenan, Ferdinand Roelfsema, Ali Iranmanesh

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Aging is marked by depletion of adrenal androgens (DHEAs) in the face of elevated late-day total cortisol concentrations. CRH and AVP evoke greater ACTH and cortisol responses in older than young adults, especially in postmenopausal women. The joint synchrony and strength of cortisol→ACTH negative feedback decline with aging. Further studies are required to elucidate the precise mechanisms mediating and the long-term impact of impaired stress adaptations in aging.

Original languageEnglish (US)
Pages (from-to)993-1014
Number of pages22
JournalEndocrinology and Metabolism Clinics of North America
Issue number4
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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