TY - JOUR
T1 - Aging, Cell Senescence, and Chronic Disease
T2 - Emerging Therapeutic Strategies
AU - Tchkonia, Tamara
AU - Kirkland, James L.
N1 - Funding Information:
Drs Tchkonia and Kirkland reported receiving grants from the National Institutes of Health (AG13925), The Connor Group, the Noaber Foundation, Robert J. and TheresaW. Ryan, and the Ted Nash Long Life Foundation as well as a BIG Award from the Glenn Foundation for Medical Research in partnership with the American Federation for Aging Research.
Funding Information:
have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Drs Tchkonia and Kirkland reported receiving grants from the National Institutes of Health (AG13925), The Connor Group, the Noaber Foundation, Robert J. and Theresa W. Ryan, and the Ted Nash Long Life Foundation as well as a BIG Award from the Glenn Foundation for Medical Research in partnership with the American Federation for Aging Research. Drs Tchkonia and Kirkland also reported holding a patent on senolytic drugs assigned to Mayo Clinic and that Mayo Clinic licensed to Unity Biotechnology.
Publisher Copyright:
© 2018 American Medical Association. All rights reserved.
PY - 2018/10/2
Y1 - 2018/10/2
N2 - This Viewpoint describes the processes by which aging of cells contributes to age-related decline, chronic disease, and multimorbidity, and describes current animal research and clinical trials investigating the effects of senolytic drugs and vaccines that target senescent cell antiapoptotic pathways and remove senescent cells.
AB - This Viewpoint describes the processes by which aging of cells contributes to age-related decline, chronic disease, and multimorbidity, and describes current animal research and clinical trials investigating the effects of senolytic drugs and vaccines that target senescent cell antiapoptotic pathways and remove senescent cells.
UR - http://www.scopus.com/inward/record.url?scp=85053687190&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053687190&partnerID=8YFLogxK
U2 - 10.1001/jama.2018.12440
DO - 10.1001/jama.2018.12440
M3 - Review article
C2 - 30242336
AN - SCOPUS:85053687190
SN - 0098-7484
VL - 320
SP - 1319
EP - 1320
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
IS - 13
ER -