Aggressive basal cell carcinoma: Presentation, pathogenesis, and management

Hobart W. Walling, Scott W. Fosko, Pedram A. Geraminejad, Duane C. Whitaker, Christopher J. Arpey

Research output: Contribution to journalReview articlepeer-review

211 Scopus citations


Basal cell carcinoma (BCC) is the most common cutaneous skin malignancy. BCC generally has a clinical course characterized by slow growth, minimal soft tissue invasiveness, and a high cure rate. Occasionally, however, BCC behaves aggressively with deep invasion, recurrence, and potential regional and distant metastasis. Several factors, including tumor size, duration, histology, and perineural spread, have been postulated as markers of the aggressive BCC phenotype. It is undetermined whether intrinsic biological factors within certain subsets of BCC predispose these tumors toward an inherently aggressive behavior, or whether any BCC with inadequate early management may assume this phenotype. Review of the pertinent literature on this topic suggests that both intrinsic biological factors and extrinsic management factors play a role in the development and progression of aggressive BCC.

Original languageEnglish (US)
Pages (from-to)389-402
Number of pages14
JournalCancer and Metastasis Reviews
Issue number3-4
StatePublished - Aug 2004


  • Bcl2
  • cryotherapy
  • curettage
  • cyclin
  • imiquimod
  • pyrimidine dimer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Aggressive basal cell carcinoma: Presentation, pathogenesis, and management'. Together they form a unique fingerprint.

Cite this