Age-related memory decline and apolipoprotein E e4.

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The APOE epsilon4 allele is associated with risk of late-onset Alzheimer's disease (AD). Longitudinal memory decline in asymptomatic APOE epsilon4 carriers shows greater acceleration compared with non-carriers, with a possible allele-dose effect, and begins prior to age 60. These results correlate with imaging and neuropathological studies that show AD-like changes at this age and collectively support the existence of a presymptomatic stage of AD.

Original languageEnglish (US)
Pages (from-to)47-50
Number of pages4
JournalDiscovery Medicine
Issue number41
StatePublished - Aug 2009

ASJC Scopus subject areas

  • Medicine(all)


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