Abstract
The APOE epsilon4 allele is associated with risk of late-onset Alzheimer's disease (AD). Longitudinal memory decline in asymptomatic APOE epsilon4 carriers shows greater acceleration compared with non-carriers, with a possible allele-dose effect, and begins prior to age 60. These results correlate with imaging and neuropathological studies that show AD-like changes at this age and collectively support the existence of a presymptomatic stage of AD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 47-50 |
| Number of pages | 4 |
| Journal | Discovery Medicine |
| Volume | 8 |
| Issue number | 41 |
| State | Published - Aug 2009 |
ASJC Scopus subject areas
- Medicine(all)