Age, family history, and memory and future risk for cognitive impairment

Dona E.C. Locke, Robert J. Ivnik, Ruth H. Cha, David S. Knopman, Eric G. Tangalos, Bradley F. Boeve, Ronald C. Petersen, Glenn E. Smith

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Purpose: To provide a clinical tool for calculating a patient's future risk for developing cognitive impairment based on age, family history, and Rey Auditory Verbal Learning Test (AVLT) retention. Participants: 1,019 cognitively normal persons followed for an average of 5 years; 159 participants were eventually diagnosed with cognitive impairment. Results: Risk of developing cognitive impairment increases with age and family history, but decreases with better memory performance. A nomogram is provided for calculation of relative risk of developing cognitive impairment in combinations of age, family history, and memory performance. Conclusions: These results enhance clinicians' ability to provide information to a patient about risk of cognitive impairment.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalJournal of Clinical and Experimental Neuropsychology
Issue number1
StatePublished - Jan 2009


  • Cognitive decline
  • Dementia
  • Family history
  • Rey auditory verbal learning test
  • Risk

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Neurology
  • Clinical Neurology


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