Age, anatomic site, and the replication and differentiation of adipocyte precursors

J. L. Kirkland, C. H. Hollenberg, W. S. Gillon

Research output: Contribution to journalArticlepeer-review

152 Scopus citations


The effects of donor age and anatomic site on cellular replication and differentiation were studied in adipocyte precursors cloned from epididymal and perirenal depots of young, middle-aged, and senescent rats. As animals aged from 3 to 29 mo, there was a progressive reduction in the proportion of cells capable of extensive replication in both depots. An inverse relation between clonal capacity for replication and differentiation was found. This relation was affected by donor site but not age. Aging was, however, associated with a reduction in the frequency of clones capable of full differentiation into cells with single, large, central lipid inclusions. Hence, age and donor site may affect adipocyte precursor replication and differentiation by different mechanisms.

Original languageEnglish (US)
Pages (from-to)C206-C210
JournalAmerican Journal of Physiology - Cell Physiology
Issue number2 27-2
StatePublished - 1990


  • cell doublings
  • fat cells
  • fat depot development
  • preadipocytes
  • senescence

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


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