Adverse outcomes associated with noncompliance with melanoma treatment guidelines

Jennifer Erickson Foster, Josè M. Velasco, Tina J. Hieken

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Background: Clinical practice guidelines have been developed to improve melanoma patient care. However, it is unclear whether failure to comply with these standards (either excessive or inadequate treatment) increases morbidity or relapse rates. Therefore, we undertook this study to evaluate the effect of variance from National Comprehensive Cancer Network (NCCN) recommendations on postoperative complication rates and disease recurrence. Methods: We retrospectively reviewed our institutional cancer registry data on 327 clinically node-negative melanoma patients and assessed compliance with NCCN guidelines, complication rates, and outcome. Data were confirmed by chart, pathology report, and operative note review. Statistical analysis was performed by using the SAS statistical software package. Results: Postoperative complications were documented in 17% of patients and were 3.4-fold higher for patients treated in a margin-noncompliant fashion and 2.4-fold higher for patients treated in a lymph-node-noncompliant manner (P < 0.001 for both). After mean follow-up of 51 months, disease recurred in 58 patients (18%) at a mean of 33 months (range 4-93 months). Locoregional disease alone as the first site of relapse was seen in 24% of margin-noncompliant versus 6% of margin-compliant cases and in 33% of lymph-node-noncompliant versus 6% of lymph-node-compliant cases (P < 0.0001). Conclusion: While there are valid reasons for variance from treatment algorithms, these data suggest that compliance with NCCN guidelines improves outcome and decreases morbidity in clinically node-negative melanoma patients.

Original languageEnglish (US)
Pages (from-to)2395-2402
Number of pages8
JournalAnnals of surgical oncology
Issue number9
StatePublished - Sep 2008


  • Adverse outcomes
  • Melanoma
  • Surgical treatment
  • Treatment guidelines

ASJC Scopus subject areas

  • Surgery
  • Oncology


Dive into the research topics of 'Adverse outcomes associated with noncompliance with melanoma treatment guidelines'. Together they form a unique fingerprint.

Cite this