Advances in pulmonary laboratory testing

Bruce D. Johnson, Kenneth C. Beck, R. Jorge Zeballos, Idelle M. Weisman

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


This review examines emerging technologies that are of potential use in the routine clinical pulmonary laboratory. These technologies include the following: the measurement of exercise tidal flow-volume (FV) loops plotted within the maximal FV envelope for assessment of ventilatory constraint during exercise; the use of negative expiratory pressures to asses expiratory flow limitation in various populations and under various conditions; the potential use of expired nitric oxide for assessing airway inflammation; and the use of forced oscillation for assessment of airway resistance. These methodologies have been used extensively in the research setting and are gaining increasing popularity and clinical application due to the availability of commercially available, simplified, and automated systems. An overview of each technique, its potential advantages and limitations will be discussed, along with suggestions for further investigation that is considered necessary prior to extensive clinical use.

Original languageEnglish (US)
Pages (from-to)1377-1387
Number of pages11
Issue number5
StatePublished - 1999


  • Flow-volume
  • Forced oscillation
  • Negative expiratory pressure
  • Nitric oxide

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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