@article{89c2f6a0f713480eb8fea5ef36f0aeed,
title = "Advances in Closed-Loop Insulin Delivery Systems in Patients with Type 1 Diabetes",
abstract = "Purpose of Review: To provide a current review of closed-loop insulin delivery or artificial pancreas (AP) as therapy for people with type 1 diabetes mellitus (T1D) Recent Findings: The Medtronic Minimed 670G AP system has been in use in clinical practice since March 2017. Currently, Medtronic is conducting a large randomized clinical trial to evaluate its efficacy further in T1D. Simultaneously, the NIH has funded four research consortia to accelerate progress to approval of other AP and decision support systems. Several research groups are currently developing next-generation AP systems, with a number of companies moving toward releasing closed-loop systems in the future. AP systems are also being tested in select populations such as hypoglycemia-unaware T1D and pregnant T1D. Summary: AP research is rapidly advancing. The clinical range of AP will be expanded in the next decade.",
keywords = "Artificial pancreas, Closed loop, Glycemic variability, Hypoglycemia, Type 1 diabetes",
author = "Vikash Dadlani and Pinsker, {Jordan E.} and Eyal Dassau and Kudva, {Yogish C.}",
note = "Funding Information: Yogish C. Kudva is currently a co-investigator on NIH-funded AP studies, has received funding for AP research from JDRF and Helmsley Charitable Trust, has conducted AP research sponsored by Medtronic, and has received research support to his institution from Tandem, Roche, and Dexcom. He also has a patent issued (US9486172B2), Assignee: Universita degli Studi di Padova, Padua (IT). Funding Information: Jordan E. Pinsker is currently a co-investigator on NIH-funded AP studies; has received funding for AP research from JDRF and Helmsley Charitable Trust; has conducted AP research sponsored by Tandem, Insulet, and Bigfoot Biomedical; has received speaker{\textquoteright}s bureau fees from Tandem; and has received research support to his institution as principal investigator from Animas, Tandem, Ascensia, Insulet, Lifescan, Roche, and Dexcom. Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2018",
month = oct,
day = "1",
doi = "10.1007/s11892-018-1051-z",
language = "English (US)",
volume = "18",
journal = "Current diabetes reports",
issn = "1534-4827",
publisher = "Current Medicine Group",
number = "10",
}