Advances in Cardiac Electrophysiology

Jonathan P. Piccini, Andrea M. Russo, Parikshit S. Sharma, Jordana Kron, Wendy Tzou, William Sauer, David S. Park, Ulrika Birgersdotter-Green, David S. Frankel, Jeff S. Healey, John Hummel, Jacob Koruth, Dominik Linz, Suneet Mittal, Devi G. Nair, Stanley Nattel, Peter A. Noseworthy, Benjamin A. Steinberg, Natalia A. Trayanova, Elaine Y. WanErik Wissner, Emily P. Zeitler, Paul J. Wang

Research output: Contribution to journalReview articlepeer-review


Despite the global COVID-19 pandemic, during the past 2 years, there have been numerous advances in our understanding of arrhythmia mechanisms and diagnosis and in new therapies. We increased our understanding of risk factors and mechanisms of atrial arrhythmias, the prediction of atrial arrhythmias, response to treatment, and outcomes using machine learning and artificial intelligence. There have been new technologies and techniques for atrial fibrillation ablation, including pulsed field ablation. There have been new randomized trials in atrial fibrillation ablation, giving insight about rhythm control, and long-term outcomes. There have been advances in our understanding of treatment of inherited disorders such as catecholaminergic polymorphic ventricular tachycardia. We have gained new insights into the recurrence of ventricular arrhythmias in the setting of various conditions such as myocarditis and inherited cardiomyopathic disorders. Novel computational approaches may help predict occurrence of ventricular arrhythmias and localize arrhythmias to guide ablation. There are further advances in our understanding of noninvasive radiotherapy. We have increased our understanding of the role of His bundle pacing and left bundle branch area pacing to maintain synchronous ventricular activation. There have also been significant advances in the defibrillators, cardiac resynchronization therapy, remote monitoring, and infection prevention. There have been advances in our understanding of the pathways and mechanisms involved in atrial and ventricular arrhythmogenesis.

Original languageEnglish (US)
Pages (from-to)E009911
JournalCirculation: Arrhythmia and Electrophysiology
Issue number12
StatePublished - Dec 1 2022


  • arrhythmias, cardiac
  • atrial fibrillation
  • cardiac electrophysiology
  • defibrillators, implantable
  • tachycardia, ventricular

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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