Advances and Future Directions in Cardiac Pacemakers: Part 2 of a 2-Part Series

Malini Madhavan, Siva K. Mulpuru, Christopher J. McLeod, Yong Mei Cha, Paul A. Friedman

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


In the second part of this 2-part series on pacemakers, we present recent advances in pacemakers and preview future developments. Cardiac resynchronization therapy (CRT) is a potent treatment for heart failure in the setting of ventricular dyssynchrony. Successful CRT using coronary venous pacing depends on appropriate patient selection, lead implantation, and device programming. Despite optimization of these factors, nonresponse to CRT may occur in one-third of patients, which has led to a search for alternative techniques such as multisite pacing, His bundle pacing, and endocardial left ventricular pacing. A paradigm shift in pacemaker technology has been the development of leadless pacemaker devices, and on the horizon is the development of batteryless devices. Remote monitoring has ushered in an era of greater safety and the ability to respond to device malfunction in a timely fashion, improving outcomes.

Original languageEnglish (US)
Pages (from-to)211-235
Number of pages25
JournalJournal of the American College of Cardiology
Issue number2
StatePublished - Jan 17 2017


  • His bundle pacing
  • leadless pacing
  • remote monitoring
  • resynchronization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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