Adenocarcinoma of the distal bile duct. A clinicopathologic outcome analysis after curative resection

Luca Bortolasi, Lawrence J. Burgart, Gregory G. Tsiotos, Enrique Luque-de León, Michael G. Sarr

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Background/Aims: Primary distal bile duct adenocarcinomas (DBDAs) are unusual neoplasms, necessitating pancreaticoduodenectomy for cure. The aims of this study were to evaluate the prognostic importance of lymphatic and perineural invasion, long-term outcome of patients after resection, and differences in outcome with hilar cholangiocarcinoma and pancreatic carcinoma. Methods: The medical records and histopathological slides of 15 patients (8 men and 7 women) with documented DBDA after curative pancreaticoduodenectomy were reviewed. Results: Nine standard and 6 pylorus-preserving pancreaticoduodenectomies were performed. TNM staging included 1, 3, 2, 8, and 1 patient in stages I, II, III, and IVA and IVB, respectively. Lymphatic and perineural invasion was present in 4 (27%) and 9 (60%) patients, respectively. With multivariate analysis only serum bilirubin was a significant prognostic factor. Median survival was 21 months, and 2- and 5-year actuarial survivals were 40 and 20%, respectively. Median survival with adjuvant therapy (n = 6) was 21 months, with 5-year survival of 33%. Five-year actuarial survivals when lymphatic or perineural invasion was present were 0 and 11%, respectively. Conclusion: DBDA is aggressive, but entails a better prognosis than pancreatic ductal or more proximal bile duct carcinoma. Lymphatic and/or perineural invasion worsen survival. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)36-41
Number of pages6
JournalDigestive Surgery
Issue number1
StatePublished - Jan 1 2000


  • Bile duct cancer
  • Cholangiocarcinoma
  • Pancreaticoduodenectomy
  • Periampullary carcinoma

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology


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