Acute Treatment of Headache (Focus on Migraine)

Chia Chun Chiang, Rashmi B. Halker Singh

Research output: Contribution to journalArticlepeer-review


Acute treatments for migraine and cluster headache are necessary to abort attacks, relieve pain and associated symptoms, and restore an individual's ability to function. Acute headache treatments consist of a variety of medication and nonmedication options. In this article, we discuss the approach to acute treatment of migraine and cluster headache. We summarize the level of evidence to support each acute medication class according to recent systematic reviews and meta-analyses, as well as guideline recommendations from the American Headache Society, American Academy of Neurology, and European Federation of Neurological Society.

Original languageEnglish (US)
Pages (from-to)494-502
Number of pages9
JournalSeminars in Neurology
Issue number4
StatePublished - Nov 2 2022


  • acute treatment
  • calcitonin gene-related peptide
  • cluster headache
  • migraine
  • triptans

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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