Acute Pancreatitis

Georgios Papachristou, Vijay Singh, David C. Whitcomb

Research output: Chapter in Book/Report/Conference proceedingChapter


Acute pancreatitis is an inflammatory response to pancreatic injury., The response can be mild and local, or extend to peripancreatic and systemic inflammation. The systemic inflammatory response can also lead to vascular leak, pulmonary edema, hypovolemia hypotension and shock, and ischemic injury to the pancreas, kidney and intestines. The most common etiologies of acute pancreatitis are gallstones, alcoholism, and idiopathic. Treatment is initially aimed at fluid resuscitation, support of organ dysfunction, and in severe cases enteral feeding. Therapeutic endoscopy may be needed to dislodge an impacted gallstone to treat bacterial cholangitis. Treatment is supportive, and a plan to prevent recurrence should be implemented before discharge.

Original languageEnglish (US)
Title of host publicationTextbook of Clinical Gastroenterology and Hepatology
Subtitle of host publicationSecond Edition
Number of pages7
ISBN (Print)1405191821, 9781405191821
StatePublished - Apr 16 2012


  • Acute pancreatitis
  • Cholangitis
  • Multi-organ failure
  • Pancreatic necrosis
  • Systemic inflammation
  • Systemic inflammatory response syndrome
  • Trypsin
  • Vascular leak

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Acute Pancreatitis'. Together they form a unique fingerprint.

Cite this