Acute panautonomic neuropathy

P. A. Low, P. J. Dyck, E. H. Lambert, W. S. Brimijoin, J. C. Trautmann, J. R. Malagelada, R. D. Fealey, D. M. Barrett

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Two patients with acute panautonomic neuropathy had severe impairment of sympathetic and parasympathetic function of acute onset. Autonomic tests suggesting a postganglionic lesion and direct evidence of loss of unmyelinated and small myelinated fibers on nerve biopsy were found in Patient 1. There was a selective loss of small myelinated and unmyelinated nerve fibers; C potential was absent in the in vitro compound action potential; dopamine‐β‐hydroxylase activity was unmeasurable. No definite abnormalities were found on the nerve biopsy of Patient 2. The acute panautonomic neuropathies appear to comprise a spectrum of somatic and autonomic involvement.

Original languageEnglish (US)
Pages (from-to)412-417
Number of pages6
JournalAnnals of neurology
Issue number4
StatePublished - Apr 1983

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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