Acute-on-Chronic Liver Failure: Can We Agree on a Definition?

Douglas A. Simonetto; Patrick S. Kamath

doi:10.1007/s11901-015-0254-x

Acute-on-Chronic Liver Failure: Can We Agree on a Definition?

Douglas A. Simonetto, Patrick S. Kamath

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

Abstract

Acute-on-chronic liver failure (ACLF) has recently received more recognition. It is a condition characterized by acute clinical deterioration in patients with chronic liver disease and is often associated with a precipitant event. It is a form of decompensated cirrhosis characterized by the presence of extrahepatic organ failure and high short-term mortality. Several definitions have been recently proposed for ACLF; however, larger prospective studies are still needed to refine our understanding of this new entity. This article explores the most recently proposed definitions, classification, and prognostic models of ACLF.

Original language	English (US)
Pages (from-to)	40-45
Number of pages	6
Journal	Current Hepatitis Reports
Volume	14
Issue number	1
DOIs	https://doi.org/10.1007/s11901-015-0254-x
State	Published - Jan 1 2015

Keywords

Cirrhosis
Hepatic decompensation
Liver failure
Multiorgan failure

ASJC Scopus subject areas

Hepatology
Virology

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10.1007/s11901-015-0254-x

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title = "Acute-on-Chronic Liver Failure: Can We Agree on a Definition?",

abstract = "Acute-on-chronic liver failure (ACLF) has recently received more recognition. It is a condition characterized by acute clinical deterioration in patients with chronic liver disease and is often associated with a precipitant event. It is a form of decompensated cirrhosis characterized by the presence of extrahepatic organ failure and high short-term mortality. Several definitions have been recently proposed for ACLF; however, larger prospective studies are still needed to refine our understanding of this new entity. This article explores the most recently proposed definitions, classification, and prognostic models of ACLF.",

keywords = "Cirrhosis, Hepatic decompensation, Liver failure, Multiorgan failure",

author = "Simonetto, {Douglas A.} and Kamath, {Patrick S.}",

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AU - Simonetto, Douglas A.

AU - Kamath, Patrick S.

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Y1 - 2015/1/1

N2 - Acute-on-chronic liver failure (ACLF) has recently received more recognition. It is a condition characterized by acute clinical deterioration in patients with chronic liver disease and is often associated with a precipitant event. It is a form of decompensated cirrhosis characterized by the presence of extrahepatic organ failure and high short-term mortality. Several definitions have been recently proposed for ACLF; however, larger prospective studies are still needed to refine our understanding of this new entity. This article explores the most recently proposed definitions, classification, and prognostic models of ACLF.

AB - Acute-on-chronic liver failure (ACLF) has recently received more recognition. It is a condition characterized by acute clinical deterioration in patients with chronic liver disease and is often associated with a precipitant event. It is a form of decompensated cirrhosis characterized by the presence of extrahepatic organ failure and high short-term mortality. Several definitions have been recently proposed for ACLF; however, larger prospective studies are still needed to refine our understanding of this new entity. This article explores the most recently proposed definitions, classification, and prognostic models of ACLF.

KW - Cirrhosis

KW - Hepatic decompensation

KW - Liver failure

KW - Multiorgan failure

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JO - Current Hepatitis Reports

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IS - 1

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Acute-on-Chronic Liver Failure: Can We Agree on a Definition?

Abstract

Keywords

ASJC Scopus subject areas

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