TY - JOUR
T1 - Acute ischemic transection of peripheral axons in angiopathic neuropathy
T2 - No demyelination of fasciculus gracilis or decreased number or size of cytons of spinal ganglion neurons
AU - Ohnishi, Aklo
AU - Siekert, Friedrich A.P.
AU - Okazaki, Haruo
AU - Dyck, Peter James
PY - 1975/11
Y1 - 1975/11
N2 - Demyelination (loss of myelin profiles) of posterior columns of the spinal cord in patients with neuropathy coming to autopsy usually has been interpreted as secondary to distal degeneration of peripheral nerve fibers. Previous experiments to test whether these pathologic changes could result from transecting peripheral nerves produced conflicting results. In a patient with necrotizing angiopathy in whom extensive regions of fiber transection began proximally at midthigh level, the density and diameter distribution of myelinated fibers of the fasciculus gracilis and the number and size distribution of cytons of L3 and L5 spinal ganglia have been obtained and compared with normative measurements. No discernible alteration was found, suggesting that acute degeneration of peripheral nerve fibers is not associated with loss or decrease in size of cytons of spinal ganglia or with loss or decrease in size of myelinated fibers in the fasciculus gracilis.
AB - Demyelination (loss of myelin profiles) of posterior columns of the spinal cord in patients with neuropathy coming to autopsy usually has been interpreted as secondary to distal degeneration of peripheral nerve fibers. Previous experiments to test whether these pathologic changes could result from transecting peripheral nerves produced conflicting results. In a patient with necrotizing angiopathy in whom extensive regions of fiber transection began proximally at midthigh level, the density and diameter distribution of myelinated fibers of the fasciculus gracilis and the number and size distribution of cytons of L3 and L5 spinal ganglia have been obtained and compared with normative measurements. No discernible alteration was found, suggesting that acute degeneration of peripheral nerve fibers is not associated with loss or decrease in size of cytons of spinal ganglia or with loss or decrease in size of myelinated fibers in the fasciculus gracilis.
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U2 - 10.1212/wnl.25.11.1059
DO - 10.1212/wnl.25.11.1059
M3 - Article
C2 - 1237824
AN - SCOPUS:0016714247
SN - 0028-3878
VL - 25
SP - 1059
EP - 1064
JO - Neurology
JF - Neurology
IS - 11
ER -