Acute ischemia causes axonal stasis, swelling, attenuation, and secondary demyelination

Hitoshi Nukada, Peter James Dyck

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


Microsphere embolization of rat sciatic nerve capillaries results in a central fascicular ischemic core. Twenty‐four hours after microembolization, the pathological alterations along the length of 55 myelinated fibers were reconstructed by computer imaging of 2,000 serial semi‐thin epoxy sections of a tissue block that extended from just above and into an ischemic core. From proximal to distal, the typical sequence of pathological alternations was: normal → swollen dark axons + thin myelin or demyelination → attenuated axons → axon cytolysis (46 fibers) or normal axons (9 fibers). Because organelle accumulation and axonal swelling were the earliest and most proximal pathological lesions, we infer that regional hypoxia causes axonal stasis as a primary event. Demyelination was found in fibers showing swollen dark and attenuated axons. These findings suggest that axons are selectively vulnerable to acute ischemia and that, depending on severity, the fibers either undergo axonal degeneration or transitory structural alterations without axonal degeneration, the latter consisting of axonal changes and secondary demyelination.

Original languageEnglish (US)
Pages (from-to)311-318
Number of pages8
JournalAnnals of neurology
Issue number3
StatePublished - Sep 1987

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Acute ischemia causes axonal stasis, swelling, attenuation, and secondary demyelination'. Together they form a unique fingerprint.

Cite this