Abstract
In this study, effects of acupuncture at Zusanli acupoint on cell proliferation and expression of neuropeptide Y (NPY) in the dentate gyrus (DG) of streptozotocin-induced diabetic rats were investigated. Sprague-Dawley rats were divided into six groups: the control group, the non-diabetic and Zusanli-acupunctured group, the non-diabetic and non-acupoint-acupunctured group, the streptozotocin-induced-diabetes group, the streptozotocin-induced-diabetes and Zusanli-acupunctured group, and the streptozotocin-induced-diabetes and non-acupoint-acupunctured group. In the streptozotocin-induced diabetes group, the mean 5-bromo-2′-deoxyuridine-positive and NPY-positive cell counts in the DG were significantly decreased compared to the control group. Stimulation of the Zusanli resulted in increased cell proliferation and neuropeptide Y levels in the diabetic group. In the present results, it can be suggested that acupuncture may affect cell proliferation in the DG of streptozotocin-induced diabetic rats by regulating neuropeptide Y expression.
Original language | English (US) |
---|---|
Pages (from-to) | 33-36 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 327 |
Issue number | 1 |
DOIs | |
State | Published - Jul 12 2002 |
Keywords
- Acupuncture
- Cell proliferation
- Dentate gyrus
- Diabetes
- Neuropeptide Y
- Streptozotocin
ASJC Scopus subject areas
- General Neuroscience