Activin A plays a critical role in proliferation and differentiation of human adipose progenitors

Laure Emmanuelle Zaragosi, Brigitte Wdziekonski, Phi Villageois, Mayoura Keophiphath, Marie Maumus, Tamara Tchkonia, Virginie Bourlier, Tala Mohsen-Kanson, Annie Ladoux, Christian Elabd, Marcel Scheideler, Zlatko Trajanoski, Yasuhiro Takashima, Ez Zoubir Amri, Daniele Lacasa, Coralie Sengenes, Gérard Ailhaud, Karine Clément, Anne Bouloumie, James L. KirklandChristian Dani

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


OBJECTIVE - Growth of white adipose tissue takes place in normal development and in obesity. A pool of adipose progenitors is responsible for the formation of new adipocytes and for the potential of this tissue to expand in response to chronic energy overload. However, factors controlling self-renewal of human adipose progenitors are largely unknown. We investigated the expression profile and the role of activin A in this process. RESEARCH DESIGN AND METHODS - Expression of INHBA/activin A was investigated in three types of human adipose progenitors. We then analyzed at the molecular level the function of activin A during human adipogenesis. We finally investigated the status of activin A in adipose tissues of lean and obese subjects and analyzed macrophage-induced regulation of its expression. RESULTS - INHBA/activin A is expressed by adipose progenitors from various fat depots, and its expression dramatically decreases as progenitors differentiate into adipocytes. Activin A regulates the number of undifferentiated progenitors. Sustained activation or inhibition of the activin A pathway impairs or promotes, respectively, adipocyte differentiation via the C/EBPβ-LAP and Smad2 pathway in an autocrine/paracrine manner. Activin A is expressed at higher levels in adipose tissue of obese patients compared with the expression levels in lean subjects. Indeed, activin A levels in adipose progenitors are dramatically increased by factors secreted by macrophages derived from obese adipose tissue. CONCLUSIONS - Altogether, our data show that activin A plays a significant role in human adipogenesis. We propose a model in which macrophages that are located in adipose tissue regulate adipose progenitor self-renewal through activin A.

Original languageEnglish (US)
Pages (from-to)2513-2521
Number of pages9
Issue number10
StatePublished - Oct 2010

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


Dive into the research topics of 'Activin A plays a critical role in proliferation and differentiation of human adipose progenitors'. Together they form a unique fingerprint.

Cite this