Abstract
Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy volunteers and correlated with the presence of erosions in the patients. Immunohistological staining of MMP-2, MMP-14 and TIMP-2 localized to corresponding areas in the synovial lining layer and was almost absent in normal synovium. Patients with radiographic erosions had significantly higher levels of active MMP-2 than patients with no erosions, suggesting that activated MMP-2 levels in synovial tissue may be a marker for a more aggressive synovial lesion.
Original language | English (US) |
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Pages (from-to) | 145-153 |
Number of pages | 9 |
Journal | Arthritis Research |
Volume | 2 |
Issue number | 2 |
DOIs | |
State | Published - 2000 |
Keywords
- Early synovitis
- Erosion
- Matrix metalloproteinse-2
- Metalloproteinase
- Rheumatoid arthritis
ASJC Scopus subject areas
- Rheumatology