TY - JOUR
T1 - Accuracy of First- and Second-Generation Colon Capsules in Endoscopic Detection of Colorectal Polyps
T2 - A Systematic Review and Meta-analysis
AU - Spada, Cristiano
AU - Pasha, Shabana F.
AU - Gross, Seth A.
AU - Leighton, Jonathan A.
AU - Schnoll-Sussman, Felice
AU - Correale, Loredana
AU - González Suárez, Begoña
AU - Costamagna, Guido
AU - Hassan, Cesare
N1 - Publisher Copyright:
© 2016 AGA Institute
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Background & Aims Colon capsule endoscopy (CCE) is a noninvasive technique used to explore the colon without sedation or air insufflation. A second-generation capsule was recently developed to improve accuracy of detection, and clinical use has expanded globally. We performed a systematic review and meta-analysis to assess the accuracy of CCE in detecting colorectal polyps. Methods We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and other databases from 1966 through 2015 for studies that compared accuracy of colonoscopy with histologic evaluation with CCE. The risk of bias within each study was ascertained according to Quality Assessment of Diagnostic Accuracy in Systematic Reviews recommendations. Per-patient accuracy values were calculated for polyps, overall and for first-generation (CCE-1) and second-generation (CCE-2) capsules. We analyzed data by using forest plots, the I2 statistic to calculate heterogeneity, and meta-regression analyses. Results Fourteen studies provided data from 2420 patients (1128 for CCE-1 and 1292 for CCE-2). CCE-2 and CCE-1 detected polyps >6 mm with 86% sensitivity (95% confidence interval [CI], 82%–89%) and 58% sensitivity (95% CI, 44%–70%), respectively, and 88.1% specificity (95% CI, 74.2%–95.0%) and 85.7% specificity (95% CI, 80.2%–90.0%), respectively. CCE-2 and CCE-1 detected polyps >10 mm with 87% sensitivity (95% CI, 81%–91%) and 54% sensitivity (95% CI, 29%–77%), respectively, and 95.3% specificity (95% CI, 91.5%–97.5%) and 97.4% specificity (95% CI, 96.0%–98.3%), respectively. CCE-2 identified all 11 invasive cancers detected by colonoscopy. Conclusions The sensitivity in detection of polyps >6 mm and >10 mm increased substantially between development of first-generation and second-generation colon capsules. High specificity values for detection of polyps by CCE-2 seem to be achievable with a 10-mm cutoff and in a screening setting.
AB - Background & Aims Colon capsule endoscopy (CCE) is a noninvasive technique used to explore the colon without sedation or air insufflation. A second-generation capsule was recently developed to improve accuracy of detection, and clinical use has expanded globally. We performed a systematic review and meta-analysis to assess the accuracy of CCE in detecting colorectal polyps. Methods We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and other databases from 1966 through 2015 for studies that compared accuracy of colonoscopy with histologic evaluation with CCE. The risk of bias within each study was ascertained according to Quality Assessment of Diagnostic Accuracy in Systematic Reviews recommendations. Per-patient accuracy values were calculated for polyps, overall and for first-generation (CCE-1) and second-generation (CCE-2) capsules. We analyzed data by using forest plots, the I2 statistic to calculate heterogeneity, and meta-regression analyses. Results Fourteen studies provided data from 2420 patients (1128 for CCE-1 and 1292 for CCE-2). CCE-2 and CCE-1 detected polyps >6 mm with 86% sensitivity (95% confidence interval [CI], 82%–89%) and 58% sensitivity (95% CI, 44%–70%), respectively, and 88.1% specificity (95% CI, 74.2%–95.0%) and 85.7% specificity (95% CI, 80.2%–90.0%), respectively. CCE-2 and CCE-1 detected polyps >10 mm with 87% sensitivity (95% CI, 81%–91%) and 54% sensitivity (95% CI, 29%–77%), respectively, and 95.3% specificity (95% CI, 91.5%–97.5%) and 97.4% specificity (95% CI, 96.0%–98.3%), respectively. CCE-2 identified all 11 invasive cancers detected by colonoscopy. Conclusions The sensitivity in detection of polyps >6 mm and >10 mm increased substantially between development of first-generation and second-generation colon capsules. High specificity values for detection of polyps by CCE-2 seem to be achievable with a 10-mm cutoff and in a screening setting.
KW - Colorectal Cancer
KW - Colorectal Cancer Screening
KW - Imaging
KW - PillCam
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U2 - 10.1016/j.cgh.2016.04.038
DO - 10.1016/j.cgh.2016.04.038
M3 - Review article
C2 - 27165469
AN - SCOPUS:84995495122
SN - 1542-3565
VL - 14
SP - 1533-1543.e8
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 11
ER -