Acceleration and augmentation strategies for treating bipolar depression

Lori L. Altshuler, Mark A. Frye, Michael J. Gitlin

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Despite the prevalence and morbidity of bipolar depression, few randomized treatment trials have been conducted to assess clinical efficacy. Even fewer studies have assessed approaches that optimize treatment response for bipolar depression. This review will define three types of common combination strategies-adjunctive, acceleration and augmentation-and discuss the limited literature of controlled studies reported on acceleration and augmentation approaches.

Original languageEnglish (US)
Pages (from-to)691-700
Number of pages10
JournalBiological psychiatry
Issue number8
StatePublished - Apr 15 2003


  • Acceleration
  • Adjunctive
  • Augmentation
  • Bipolar depression
  • Treatment

ASJC Scopus subject areas

  • Biological Psychiatry


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