Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review

Supriya Behl; Sunil Mehta; Mukesh K. Pandey

doi:10.3389/fnmol.2020.586209

Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review

Supriya Behl, Sunil Mehta, Mukesh K. Pandey

Radiology

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1 Scopus citations

Abstract

The aim of the present review is to summarize the prevalence of abnormal levels of various metal micronutrients including copper (Cu), iron (Fe), magnesium (Mg), zinc (Zn), and selenium (Se) in Autism Spectrum Disorder (ASD) using hair, nail and serum samples. A correlation of selected abnormal metal ions with known neurodevelopmental processes using Gene Ontology (GO) term was also conducted. Data included in this review are derived from ASD clinical studies performed globally. Metal ion disparity data is also analyzed and discussed based on gender (Male/Female) to establish any gender dependent correlation. Finally, a rational perspective and possible path to better understand the role of metal micronutrients in ASD is suggested.

Original language	English (US)
Article number	586209
Journal	Frontiers in Molecular Neuroscience
Volume	13
DOIs	https://doi.org/10.3389/fnmol.2020.586209
State	Published - Dec 10 2020

Keywords

biometals
copper
iron
magnesium
metal micronutrients
selenium and autism spectrum disorder
zinc

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.3389/fnmol.2020.586209

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title = "Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review",

abstract = "The aim of the present review is to summarize the prevalence of abnormal levels of various metal micronutrients including copper (Cu), iron (Fe), magnesium (Mg), zinc (Zn), and selenium (Se) in Autism Spectrum Disorder (ASD) using hair, nail and serum samples. A correlation of selected abnormal metal ions with known neurodevelopmental processes using Gene Ontology (GO) term was also conducted. Data included in this review are derived from ASD clinical studies performed globally. Metal ion disparity data is also analyzed and discussed based on gender (Male/Female) to establish any gender dependent correlation. Finally, a rational perspective and possible path to better understand the role of metal micronutrients in ASD is suggested.",

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AB - The aim of the present review is to summarize the prevalence of abnormal levels of various metal micronutrients including copper (Cu), iron (Fe), magnesium (Mg), zinc (Zn), and selenium (Se) in Autism Spectrum Disorder (ASD) using hair, nail and serum samples. A correlation of selected abnormal metal ions with known neurodevelopmental processes using Gene Ontology (GO) term was also conducted. Data included in this review are derived from ASD clinical studies performed globally. Metal ion disparity data is also analyzed and discussed based on gender (Male/Female) to establish any gender dependent correlation. Finally, a rational perspective and possible path to better understand the role of metal micronutrients in ASD is suggested.

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Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review

Abstract

Keywords

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