A systematic review of treatment of intermittent claudication in the lower extremities

Rafael D. Malgor, Fares Alalahdab, Tarig A. Elraiyah, Adnan Z. Rizvi, Melanie A. Lane, Larry J. Prokop, Olivia J. Phung, Wigdan Farah, Victor M. Montori, Michael S. Conte, Mohammad Hassan Murad

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations


Background Peripheral arterial disease is common and is associated with significant morbidity and mortality. Methods We conducted a systematic review to identify randomized trials and systematic reviews of patients with intermittent claudication to evaluate surgery, endovascular therapy, and exercise therapy. Outcomes of interest were death, amputation, walking distance, quality of life, measures of blood flow, and cost. Results We included eight systematic reviews and 12 trials enrolling 1548 patients. Data on mortality and amputation and on cost-effectiveness were sparse. Compared with medical management, each of the three treatments (surgery, endovascular therapy, and exercise therapy) was associated with improved walking distance, claudication symptoms, and quality of life (high-quality evidence). Evidence supporting superiority of one of the three approaches was limited. However, blood flow parameters improved faster and better with both forms of revascularization compared with exercise or medical management (low- to moderate-quality evidence). Compared with endovascular therapy, open surgery may be associated with longer length of hospital stay and higher complication rate but resulted in more durable patency (moderate-quality evidence). Conclusions In patients with claudication, open surgery, endovascular therapy, and exercise therapy were superior to medical management in terms of walking distance and claudication. Choice of therapy should rely on patients' values and preferences, clinical context, and availability of operative expertise.

Original languageEnglish (US)
Pages (from-to)54S-73S
JournalJournal of vascular surgery
Issue number3
StatePublished - Mar 1 2015

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'A systematic review of treatment of intermittent claudication in the lower extremities'. Together they form a unique fingerprint.

Cite this