A systematic review of the use of Botulinum toxin type A with subpectoral breast implants

Sebastian Winocour, Mohammad Hassan Murad, Mahsa Bidgoli-Moghaddam, Steven R. Jacobson, Uldis Bite, Michel Saint-Cyr, Nho V. Tran, Valerie Lemaine

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Objective To determine the efficacy of Botulinum toxin A (BTX-A) injections for pain relief following placement of subpectoral tissue expanders and breast implants. Methods MEDLINE and EMBASE were searched from their inception to December 2012 to identify studies reporting the efficacy of perioperative BTX-A injections following breast surgery with subpectoral prostheses. Study designs included controlled and uncontrolled studies. Results Seven studies met the inclusion criteria (2 prospective controlled cohort, 3 retrospective cohort and 2 case series). Five studies assessed the efficacy of BTX-A and three measured pain improvement as a primary outcome. The studies enrolled 427 women: 91.8% received intraoperative BTX-A injection at the time of tissue expander breast reconstruction and 4.7% following augmentation mammaplasty. Only 3.5% of women received BTX-A injections in the postoperative setting. Overall, all the studies demonstrated improvement in pain and favorable side effect profile without any major adverse effects. However, the quality of this evidence was low. Conclusion The results of this systematic review suggest that BTX-A may alleviate postoperative pain associated with the placement of subpectoral tissue expanders and implants. The available data on outcome assessment of this practice are inconsistent and lack methodological rigor. With paucity of high-level evidence to support this practice in implant-based breast surgery, further studies are needed.

Original languageEnglish (US)
Pages (from-to)34-41
Number of pages8
JournalJournal of Plastic, Reconstructive and Aesthetic Surgery
Issue number1
StatePublished - Jan 2014


  • Botulinum toxin A
  • Breast implants
  • Breast reconstruction
  • Postoperative pain
  • Tissue expanders

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'A systematic review of the use of Botulinum toxin type A with subpectoral breast implants'. Together they form a unique fingerprint.

Cite this