Abstract
One hundred and fifteen patients with definite multiple sclerosis (M.S.) and chronic persistent fatigue were studied. This ten-week cross-over study consisted of a 2-week baseline period and two 3-week treatment periods separated by a 2-week washout. Patients received either amantadine 100 mg bid or matching placebo capsules. Fatigue, the effect of fatigue on an individually pre-selected activity and its effect on activities of daily living, were evaluated. Amantadine produced a small but statistically significant decrease in fatigue. An important placebo effect was noted. Mean fatigue during the washout period was lower than during the placebo run-in period, independently of which treatment had been given first. Side effects were numerous both on amantadine and on placebo. Only insomnia was significantly more common with amantadine.
Original language | English (US) |
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Pages (from-to) | 273-278 |
Number of pages | 6 |
Journal | Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques |
Volume | 14 |
Issue number | 3 |
DOIs | |
State | Published - Aug 1987 |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology