A randomized clinical trial of two different durations of oral cryotherapy for prevention of 5‐fluorouracil‐related stomatitis

Luann K. Rocke; Charles L. Loprinzi; Jeraldine K. Lee; Susan J. Kunselman; Rita K. Iverson; Gwen Finck; Deborah Lifsey; Kara C. Glaw; Barbara A. Stevens; Alan K. Hatfield; Nancy L. Vaught; Joan Bartel; Nancy Pierson

doi:10.1002/1097-0142(19931001)72:7<2234::AID-CNCR2820720728>3.0.CO;2-N

A randomized clinical trial of two different durations of oral cryotherapy for prevention of 5‐fluorouracil‐related stomatitis

Luann K. Rocke, Charles L. Loprinzi, Jeraldine K. Lee, Susan J. Kunselman, Rita K. Iverson, Gwen Finck, Deborah Lifsey, Kara C. Glaw, Barbara A. Stevens, Alan K. Hatfield, Nancy L. Vaught, Joan Bartel, Nancy Pierson

Medical Oncology

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

Background. The authors previously reported that 30 minutes of oral cryotherapy inhibits 5‐fluorouracil (5‐FU)‐induced stomatitis. The current trial was designed to determine whether a longer duration of cryotherapy would provide additional protection. Methods. This trial involved patients who were receiving their first course of a 5‐FU plus leucovorin chemotherapy regimen, for which stomatitis is a major doselimiting toxicity. These patients were randomized to receive either 30 or 60 minutes of oral cryotherapy given at around the same time as the 5‐FU therapy. Results. A total of 178 evaluable patients were studied. Both cryotherapy groups had similar degrees of mucositis. Conclusion. The authors continue to recommend the use of 30 minutes of oral cryotherapy for patients receiving bolus intensive courses of 5‐FU‐based chemotherapy.

Original language	English (US)
Pages (from-to)	2234-2238
Number of pages	5
Journal	Cancer
Volume	72
Issue number	7
DOIs	https://doi.org/10.1002/1097-0142(19931001)72:7<2234::AID-CNCR2820720728>3.0.CO;2-N
State	Published - Oct 1 1993

Keywords

5‐fluorouracil‐induced mucositis
chemotherapy toxicity
mucositis
oral cryotherapy
stomatitis

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19931001)72:7<2234::AID-CNCR2820720728>3.0.CO;2-N

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Rocke, L. K., Loprinzi, C. L., Lee, J. K., Kunselman, S. J., Iverson, R. K., Finck, G., Lifsey, D., Glaw, K. C., Stevens, B. A., Hatfield, A. K., Vaught, N. L., Bartel, J., & Pierson, N. (1993). A randomized clinical trial of two different durations of oral cryotherapy for prevention of 5‐fluorouracil‐related stomatitis. Cancer, 72(7), 2234-2238. https://doi.org/10.1002/1097-0142(19931001)72:7<2234::AID-CNCR2820720728>3.0.CO;2-N

Rocke, LK, Loprinzi, CL, Lee, JK, Kunselman, SJ, Iverson, RK, Finck, G, Lifsey, D, Glaw, KC, Stevens, BA, Hatfield, AK, Vaught, NL, Bartel, J & Pierson, N 1993, 'A randomized clinical trial of two different durations of oral cryotherapy for prevention of 5‐fluorouracil‐related stomatitis', Cancer, vol. 72, no. 7, pp. 2234-2238. https://doi.org/10.1002/1097-0142(19931001)72:7<2234::AID-CNCR2820720728>3.0.CO;2-N

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abstract = "Background. The authors previously reported that 30 minutes of oral cryotherapy inhibits 5‐fluorouracil (5‐FU)‐induced stomatitis. The current trial was designed to determine whether a longer duration of cryotherapy would provide additional protection. Methods. This trial involved patients who were receiving their first course of a 5‐FU plus leucovorin chemotherapy regimen, for which stomatitis is a major doselimiting toxicity. These patients were randomized to receive either 30 or 60 minutes of oral cryotherapy given at around the same time as the 5‐FU therapy. Results. A total of 178 evaluable patients were studied. Both cryotherapy groups had similar degrees of mucositis. Conclusion. The authors continue to recommend the use of 30 minutes of oral cryotherapy for patients receiving bolus intensive courses of 5‐FU‐based chemotherapy.",

keywords = "5‐fluorouracil‐induced mucositis, chemotherapy toxicity, mucositis, oral cryotherapy, stomatitis",

author = "Rocke, {Luann K.} and Loprinzi, {Charles L.} and Lee, {Jeraldine K.} and Kunselman, {Susan J.} and Iverson, {Rita K.} and Gwen Finck and Deborah Lifsey and Glaw, {Kara C.} and Stevens, {Barbara A.} and Hatfield, {Alan K.} and Vaught, {Nancy L.} and Joan Bartel and Nancy Pierson",

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AU - Loprinzi, Charles L.

AU - Lee, Jeraldine K.

AU - Kunselman, Susan J.

AU - Iverson, Rita K.

AU - Finck, Gwen

AU - Lifsey, Deborah

AU - Glaw, Kara C.

AU - Stevens, Barbara A.

AU - Hatfield, Alan K.

AU - Vaught, Nancy L.

AU - Bartel, Joan

AU - Pierson, Nancy

PY - 1993/10/1

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N2 - Background. The authors previously reported that 30 minutes of oral cryotherapy inhibits 5‐fluorouracil (5‐FU)‐induced stomatitis. The current trial was designed to determine whether a longer duration of cryotherapy would provide additional protection. Methods. This trial involved patients who were receiving their first course of a 5‐FU plus leucovorin chemotherapy regimen, for which stomatitis is a major doselimiting toxicity. These patients were randomized to receive either 30 or 60 minutes of oral cryotherapy given at around the same time as the 5‐FU therapy. Results. A total of 178 evaluable patients were studied. Both cryotherapy groups had similar degrees of mucositis. Conclusion. The authors continue to recommend the use of 30 minutes of oral cryotherapy for patients receiving bolus intensive courses of 5‐FU‐based chemotherapy.

AB - Background. The authors previously reported that 30 minutes of oral cryotherapy inhibits 5‐fluorouracil (5‐FU)‐induced stomatitis. The current trial was designed to determine whether a longer duration of cryotherapy would provide additional protection. Methods. This trial involved patients who were receiving their first course of a 5‐FU plus leucovorin chemotherapy regimen, for which stomatitis is a major doselimiting toxicity. These patients were randomized to receive either 30 or 60 minutes of oral cryotherapy given at around the same time as the 5‐FU therapy. Results. A total of 178 evaluable patients were studied. Both cryotherapy groups had similar degrees of mucositis. Conclusion. The authors continue to recommend the use of 30 minutes of oral cryotherapy for patients receiving bolus intensive courses of 5‐FU‐based chemotherapy.

KW - 5‐fluorouracil‐induced mucositis

KW - chemotherapy toxicity

KW - mucositis

KW - oral cryotherapy

KW - stomatitis

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A randomized clinical trial of two different durations of oral cryotherapy for prevention of 5‐fluorouracil‐related stomatitis

Abstract

Keywords

ASJC Scopus subject areas

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