A quantitative symmetry-based analysis of hyperacute ischemic stroke lesions in noncontrast computed tomography

Roman Peter, Panagiotis Korfiatis, Daniel Blezek, A. Oscar Beitia, Irena Stepan-Buksakowska, Daniel Horinek, Kelly D. Flemming, Bradley J. Erickson

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


PURPOSE: Early identification of ischemic stroke plays a significant role in treatment and potential recovery of damaged brain tissue. In noncontrast CT (ncCT), the differences between ischemic changes and healthy tissue are usually very subtle during the hyperacute phase (< 8 h from the stroke onset). Therefore, visual comparison of both hemispheres is an important step in clinical assessment. A quantitative symmetry-based analysis of texture features of ischemic lesions in noncontrast CT images may provide an important information for differentiation of ischemic and healthy brain tissue in this phase.

METHODS: One hundred thirty-nine (139) ncCT scans of hyperacute ischemic stroke with follow-up magnetic resonance diffusion-weighted (MR-DW) images were collected. The regions of stroke were identified in the MR-DW images, which were spatially aligned to corresponding ncCT images. A state-of-the-art symmetric diffeomorphic image registration was utilized for the alignment of CT and MR-DW, for identification of individual brain hemispheres, and for localization of the region representing healthy tissue contralateral to the stroke cores. Texture analysis included extraction and classification of co-occurrence and run-length texture-based image features in the regions of ischemic stroke and their contralateral regions.

RESULTS: The classification schemes achieved area under the receiver operating characteristic [Az] ≈ 0.82 for the whole dataset. There was no statistically significant difference in the performance of classifiers for the data sets with time between 2 and 8 hours from symptom onset. The performance of the classifiers did not depend on the size of the stroke regions.

CONCLUSIONS: The results provide a set of optimal texture features which are suitable for distinguishing between hyperacute ischemic lesions and their corresponding contralateral brain tissue in noncontrast CT. This work is an initial step toward development of an automated decision support system for detection of hyperacute ischemic stroke lesions on noncontrast CT of the brain.

Original languageEnglish (US)
Pages (from-to)192-199
Number of pages8
JournalMedical physics
Issue number1
StatePublished - Jan 1 2017


  • hyperacute ischemic stroke
  • image registration
  • noncontrast computed tomography (ncCT) classification
  • texture analysis

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'A quantitative symmetry-based analysis of hyperacute ischemic stroke lesions in noncontrast computed tomography'. Together they form a unique fingerprint.

Cite this