TY - JOUR
T1 - A quantitative method for measuring the changes of lung surface wave speed for assessing disease progression of interstitial lung disease
AU - Zhang, Xiaoming
AU - Zhou, Boran
AU - Bartholmai, Brian
AU - Kalra, Sanjay
AU - Osborn, Thomas
N1 - Publisher Copyright:
© 2018 World Federation for Ultrasound in Medicine & Biology
PY - 2019/3
Y1 - 2019/3
N2 - Lung ultrasound surface wave elastography (LUSWE) is a novel non-invasive technique for measuring superficial lung tissue stiffness. The purpose of the study described here was to develop LUSWE for assessment of progression in patients with interstitial lung disease (ILD). In this study, LUSWE was used to measure changes in lung surface wave speeds at 100, 150 and 200 Hz through six intercostal lung spaces for 52 patients with ILD. The mean age was 63.1 ± 12.0 y (range: 20–85, 23 male and 29 female). The follow-up interval was 9.2 ± 3.5 mo depending on each patient's return appointment and availability. For each patient, disease progression between the baseline and follow-up tests was evaluated clinically using a 7-point Likert scale comprising three grades of improvement (mild, moderate, marked), unchanged status and three grades of worsening (mild, moderate, marked). Clinical assessments were based on changes in pulmonary function tests together with high-resolution computed tomography, echocardiography and clinical evaluations. This study illustrates the correlations between changes in lung surface wave speed and clinical assessments. Correlations of changes in lung surface wave speed at lower lateral and posterior portions of the lung portions with clinical assessments were good. LUSWE provides quantitative global and regional changes in lung surface wave speed that may be useful for quantitative assessment of progression of ILD.
AB - Lung ultrasound surface wave elastography (LUSWE) is a novel non-invasive technique for measuring superficial lung tissue stiffness. The purpose of the study described here was to develop LUSWE for assessment of progression in patients with interstitial lung disease (ILD). In this study, LUSWE was used to measure changes in lung surface wave speeds at 100, 150 and 200 Hz through six intercostal lung spaces for 52 patients with ILD. The mean age was 63.1 ± 12.0 y (range: 20–85, 23 male and 29 female). The follow-up interval was 9.2 ± 3.5 mo depending on each patient's return appointment and availability. For each patient, disease progression between the baseline and follow-up tests was evaluated clinically using a 7-point Likert scale comprising three grades of improvement (mild, moderate, marked), unchanged status and three grades of worsening (mild, moderate, marked). Clinical assessments were based on changes in pulmonary function tests together with high-resolution computed tomography, echocardiography and clinical evaluations. This study illustrates the correlations between changes in lung surface wave speed and clinical assessments. Correlations of changes in lung surface wave speed at lower lateral and posterior portions of the lung portions with clinical assessments were good. LUSWE provides quantitative global and regional changes in lung surface wave speed that may be useful for quantitative assessment of progression of ILD.
KW - Disease progression tracking
KW - Interstitial lung disease
KW - Lung
KW - Lung surface wave speed
KW - Lung ultrasound surface wave elastography
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U2 - 10.1016/j.ultrasmedbio.2018.11.003
DO - 10.1016/j.ultrasmedbio.2018.11.003
M3 - Article
C2 - 30598191
AN - SCOPUS:85059148561
SN - 0301-5629
VL - 45
SP - 741
EP - 748
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 3
ER -