@article{9a46f62c89944e1d863a2c98799f5d8f,
title = "A prospective study to establish a new-onset diabetes cohort: From the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer",
abstract = "The National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases initiated the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) in 2015 (the CPDPC's origin, structure, governance, and research objectives are described in another article in this journal). One of the key objectives of CPDPC is to assemble a cohort of 10,000 subjects 50 years or older with new-onset diabetes, called the NOD cohort. Using a define, enrich, and find early detection approach, the aims of the NOD study are to (a) estimate the 3-year probability of pancreatic ductal adenocarcinoma (PDAC) in NOD (define), (b) establish a biobank of clinically annotated biospecimens from presymptomatic PDAC and control new-onset type 2 diabetes mellitus subjects, (c) conduct phase 3 validation studies of promising biomarkers for identification of incident PDAC in NOD patients (enrich), and (d) provide a platform for development of a future interventional screening protocol for early detection of PDAC in patients with NOD that incorporates imaging studies and/or clinical algorithms (find). It is expected that 85 to 100 incidences of PDAC will be diagnosed during the study period in this cohort of 10,000 patients.",
keywords = "biomarker, diabetes, high-risk group, screening, sporadic pancreatic cancer",
author = "Anirban Maitra and Ayush Sharma and Brand, {Randall E.} and {Van Den Eeden}, {Stephen K.} and Fisher, {William E.} and Hart, {Phil A.} and Hughes, {Steven J.} and Mather, {Kieren J.} and Pandol, {Stephen J.} and Park, {Walter G.} and Ziding Feng and Jose Serrano and Rinaudo, {Jo Ann S.} and Sudhir Srivastava and Chari, {Suresh T.}",
note = "Funding Information: From the *Division of Pathology and Laboratory Medicine, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX; †Division of Gastroenterology, Department of Medicine, Mayo Clinic, Rochester, MN; ‡Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, PA; §Division of Research, Kaiser Permanente Northern California, Oakland, CA; ||Division of Gastroenterology, Baylor College of Medicine, Houston, TX; ¶Division of Gastroenterology, The Ohio State University Wexner Medical Center, Columbus, OH; #Department of Surgery, College of Medicine, University of Florida Health Science Center, Gainesville, FL; **Division of Endocrinology and Metabolism, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN; ††Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA; ‡‡Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, CA; §§Department of Biostatistics, Fred Hutchinson Cancer Research Center, Seattle, WA; ||||Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD; and ¶¶Division of Cancer Prevention, National Cancer Institute, Rockville, MD. Received for publication August 6, 2018; accepted August 24, 2018. Address correspondence to: Suresh T. Chari, MD, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Sciences, 200 First St SW, Rochester, MN 55905 (e‐mail: chari.suresh@mayo.edu). Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under the following award numbers: U01DK108288, Mayo Clinic; U01DK108300, Stanford University; U01DK108306, University of Pittsburgh; U01DK108314, Cedars-Sinai Medical Center; U01DK108320, University of Florida; U01DK108323, Indiana University; U01DK108326, Baylor College of Medicine; U01DK108327, Ohio State University; U01DK108332, Kaiser Foundation Research Institute; and U01DK108328, University of Texas MD Anderson Cancer Center. The authors declare no conflict of interest. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Copyright {\textcopyright} 2018 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/MPA.0000000000001169 Publisher Copyright: {\textcopyright} 2018 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2018",
month = nov,
day = "1",
doi = "10.1097/MPA.0000000000001169",
language = "English (US)",
volume = "47",
pages = "1244--1248",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "10",
}