A Population-based Study of Incidence, Risk Factors, Clinical Spectrum, and Outcomes of Ischemic Colitis

Siddhant Yadav, Maneesh Dave, Jithinraj Edakkanambeth Varayil, W. Scott Harmsen, William J. Tremaine, Alan R. Zinsmeister, Seth R. Sweetser, L. Joseph Melton, William J. Sandborn, Edward V. Loftus

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Background and Aims: Little is known about progression of ischemic colitis (IC) among unselected patients. We aimed to estimate the incidence, risk factors, and natural history of IC in a population-based cohort in Olmsted County, Minnesota. Methods: We performed a retrospective population-based cohort and nested case-control study of IC. Each IC case was matched to 2 controls from the same population on the basis of sex, age, and closest registration number. Conditional logistic regression, the Kaplan-Meier method, and proportional hazards regression were used to assess comorbidities, estimate survival, and identify characteristics associated with survival, respectively. Results: Four hundred forty-five county residents (median age, 71.6 years; 67% female) were diagnosed with IC from 1976 through 2009 and were matched with 890 controls. The age-adjusted and sex-adjusted incidence rates of IC nearly quadrupled from 6.1 cases/100,000 person-years in 1976-1980 to 22.9/100,000 in 2005-2009. The odds for IC were significantly higher among subjects with atherosclerotic diseases; odds ratios ranged from 2.6 for individuals with coronary disease to 7.9 for individuals with peripheral vascular disease. Of IC cases, 59% survived for 5 years (95% confidence interval, 54%-64%), compared with 90% of controls (95% confidence interval, 88%-92%). Age>40 years, male sex, right-sided colon involvement, concomitant small bowel involvement, and chronic obstructive pulmonary disease were all independently associated with mortality (P < .05). Conclusions: The incidence of IC increased during the past 3 decades in a population-based cohort in Minnesota. IC typically presents in older patients with multiple comorbidities and is associated with high in-hospital mortality (11.5%) and rates of surgery (17%).

Original languageEnglish (US)
Pages (from-to)731-738.e6
JournalClinical Gastroenterology and Hepatology
Issue number4
StatePublished - Apr 1 2015


  • COPD
  • Cardiovascular Disease
  • Epidemiologic Study
  • Intestinal Vasculature

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'A Population-based Study of Incidence, Risk Factors, Clinical Spectrum, and Outcomes of Ischemic Colitis'. Together they form a unique fingerprint.

Cite this