@article{6d05d6019f0b425d8edec8c137308530,
title = "A population-based prospective study of optic neuritis",
abstract = "Background: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management. Objective: To estimate the incidence of acute ON and the rates of conversion to MS and antibody-mediated ON. Method: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly. Results: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16–66); 44 (86%) had a single episode of ON (four bilateral), while 7/51 (14%) had recurrent ON. The overall age-specific incidence was 3.28 (2.44–4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients. Conclusion: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases.",
keywords = "Epidemiology, MRI, biomarkers, clinically isolated syndrome, multiple sclerosis, neuromyelitis optica spectrum disease",
author = "K. Soelberg and S. Jarius and Skejoe, {H. P.B.} and H. Engberg and Mehlsen, {J. J.} and Nilsson, {A. C.} and Madsen, {J. S.} and M. Reindl and B. Wildemann and J. Grauslund and Kyvik, {K. O.} and Smith, {T. J.} and Lillevang, {S. T.} and F. Paul and Weinshenker, {B. G.} and N. Asgari",
note = "Funding Information: The authors thank Professor Trevor Owens and Associate Professor Rikke Leth-Larsen for suggestions and advice for the study design and Kevin K. Mortensen, MD; Carsten Bisgaard, MD; Malou H{\o}gsbro, MD; Gerda N{\o}rrelykke M{\o}ller, MD; and Alan Kimper-Karl, MD for creating facilities for patient investigation. The authors thank the Department of Neurology and Neurophysiology at Lillebaelt Hospital, in particular Louise B Jensen, RN, and Grethe G Isaksen, RN, the three departments of ophthalmology, and all the ophthalmologist in general practice in the Region of Southern Denmark and the Autoimmunity Lab at Department of Clinical Immunology, Odense University Hospital, in particular Lis Rasmussen, for technical assistance. The data manager David Hass is thanked for establishing the RED Cap database. The authors thank the following for foundation support: Region of Southern Denmark, The University of Southern Denmark, the Danish Multiple Sclerosis Society, Lillebaelt Research Foundation, and Director Jakob Madsen and Wife Olga Madsen{\textquoteright}s Foundation. B.W. and S.J. are grateful to Merck Serono and to Dietmar-Hopp-Stiftung for supporting research on NMO at the Department of Neurology, University of Heidelberg, Heidelberg, Germany; S.J. would like to thank Mrs Annemarie Eschlbeck and the Nikon Imaging Center at the University of Heidelberg for excellent technical assistance. F.P. thanks for support Funding Information: The author(s) declared receipt of the following financial support for the research, authorship, and/or publication of this article: This research has been supported by the Region of Southern Denmark, The University of Southern Denmark, The Danish Multiple Sclerosis Society (A29922 and A32030), the Lillebaelt Research Foundation, and Director Jakob Madsen and Wife Olga Madsen{\textquoteright}s Foundation. Funding Information: by the German Research Council (DFG Exc 257), the German Competence Network Multiple Sclerosis (Bundesministerium f{\"u}r Bildung und Forschung), and the Guthy Jackson Charitable Foundation. Publisher Copyright: {\textcopyright} 2017, {\textcopyright} The Author(s), 2017.",
year = "2017",
month = dec,
day = "1",
doi = "10.1177/1352458517734070",
language = "English (US)",
volume = "23",
pages = "1893--1901",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "14",
}