A population-based prospective study of optic neuritis

K. Soelberg; S. Jarius; H. P.B. Skejoe; H. Engberg; J. J. Mehlsen; A. C. Nilsson; J. S. Madsen; M. Reindl; B. Wildemann; J. Grauslund; K. O. Kyvik; T. J. Smith; S. T. Lillevang; F. Paul; B. G. Weinshenker; N. Asgari

doi:10.1177/1352458517734070

A population-based prospective study of optic neuritis

K. Soelberg, S. Jarius, H. P.B. Skejoe, H. Engberg, J. J. Mehlsen, A. C. Nilsson, J. S. Madsen, M. Reindl, B. Wildemann, J. Grauslund, K. O. Kyvik, T. J. Smith, S. T. Lillevang, F. Paul, B. G. Weinshenker, N. Asgari

Neurology

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Background: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management. Objective: To estimate the incidence of acute ON and the rates of conversion to MS and antibody-mediated ON. Method: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly. Results: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16–66); 44 (86%) had a single episode of ON (four bilateral), while 7/51 (14%) had recurrent ON. The overall age-specific incidence was 3.28 (2.44–4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients. Conclusion: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases.

Original language	English (US)
Pages (from-to)	1893-1901
Number of pages	9
Journal	Multiple Sclerosis
Volume	23
Issue number	14
DOIs	https://doi.org/10.1177/1352458517734070
State	Published - Dec 1 2017

Keywords

Epidemiology
MRI
biomarkers
clinically isolated syndrome
multiple sclerosis
neuromyelitis optica spectrum disease

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Soelberg, K., Jarius, S., Skejoe, H. P. B., Engberg, H., Mehlsen, J. J., Nilsson, A. C., Madsen, J. S., Reindl, M., Wildemann, B., Grauslund, J., Kyvik, K. O., Smith, T. J., Lillevang, S. T., Paul, F., Weinshenker, B. G., & Asgari, N. (2017). A population-based prospective study of optic neuritis. Multiple Sclerosis, 23(14), 1893-1901. https://doi.org/10.1177/1352458517734070

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title = "A population-based prospective study of optic neuritis",

abstract = "Background: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management. Objective: To estimate the incidence of acute ON and the rates of conversion to MS and antibody-mediated ON. Method: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly. Results: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16–66); 44 (86%) had a single episode of ON (four bilateral), while 7/51 (14%) had recurrent ON. The overall age-specific incidence was 3.28 (2.44–4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients. Conclusion: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases.",

keywords = "Epidemiology, MRI, biomarkers, clinically isolated syndrome, multiple sclerosis, neuromyelitis optica spectrum disease",

author = "K. Soelberg and S. Jarius and Skejoe, {H. P.B.} and H. Engberg and Mehlsen, {J. J.} and Nilsson, {A. C.} and Madsen, {J. S.} and M. Reindl and B. Wildemann and J. Grauslund and Kyvik, {K. O.} and Smith, {T. J.} and Lillevang, {S. T.} and F. Paul and Weinshenker, {B. G.} and N. Asgari",

note = "Publisher Copyright: {\textcopyright} 2017, {\textcopyright} The Author(s), 2017.",

year = "2017",

month = dec,

day = "1",

doi = "10.1177/1352458517734070",

language = "English (US)",

volume = "23",

pages = "1893--1901",

journal = "Multiple Sclerosis",

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T1 - A population-based prospective study of optic neuritis

AU - Soelberg, K.

AU - Jarius, S.

AU - Skejoe, H. P.B.

AU - Engberg, H.

AU - Mehlsen, J. J.

AU - Nilsson, A. C.

AU - Madsen, J. S.

AU - Reindl, M.

AU - Wildemann, B.

AU - Grauslund, J.

AU - Kyvik, K. O.

AU - Smith, T. J.

AU - Lillevang, S. T.

AU - Paul, F.

AU - Weinshenker, B. G.

AU - Asgari, N.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Background: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management. Objective: To estimate the incidence of acute ON and the rates of conversion to MS and antibody-mediated ON. Method: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly. Results: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16–66); 44 (86%) had a single episode of ON (four bilateral), while 7/51 (14%) had recurrent ON. The overall age-specific incidence was 3.28 (2.44–4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients. Conclusion: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases.

AB - Background: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management. Objective: To estimate the incidence of acute ON and the rates of conversion to MS and antibody-mediated ON. Method: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly. Results: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16–66); 44 (86%) had a single episode of ON (four bilateral), while 7/51 (14%) had recurrent ON. The overall age-specific incidence was 3.28 (2.44–4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients. Conclusion: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases.

KW - Epidemiology

KW - MRI

KW - biomarkers

KW - clinically isolated syndrome

KW - multiple sclerosis

KW - neuromyelitis optica spectrum disease

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DO - 10.1177/1352458517734070

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VL - 23

SP - 1893

EP - 1901

JO - Multiple Sclerosis

JF - Multiple Sclerosis

IS - 14

ER -

A population-based prospective study of optic neuritis

Abstract

Keywords

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