TY - JOUR
T1 - A pathway map of signaling events triggered upon SARS-CoV infection
AU - Parthasarathi, K. T.Shreya
AU - Munjal, Nupur S.
AU - Dey, Gourav
AU - Kumar, Abhishek
AU - Pandey, Akhilesh
AU - Balakrishnan, Lavanya
AU - Sharma, Jyoti
N1 - Funding Information:
The authors thank Alexander Mazein for providing the SBGN training and Marek Ostaszewski for his valuable suggestions to enrich the manuscript. JS is a recipient of Bio-CARe Women Scientists award by Department of Biotechnology (DBT), Government of India (Grant number-BT/PR19924/BIC/101/568/2016). LB is a recipient of National-Post doctoral fellowship scheme by Science and Engineering Research Board (SERB), Department of Science and Technology, (Project No.PDF/2017/002992).
Funding Information:
The authors thank Alexander Mazein for providing the SBGN training and Marek Ostaszewski for his valuable suggestions to enrich the manuscript. JS is a recipient of Bio-CARe Women Scientists award by Department of Biotechnology (DBT), Government of India (Grant number-BT/PR19924/BIC/101/568/2016). LB is a recipient of National-Post doctoral fellowship scheme by Science and Engineering Research Board (SERB), Department of Science and Technology, (Project No.PDF/2017/002992).
Funding Information:
This work was funded by the intramural funds of Institute of Bioinformatics, India and Bio-CARe by Department of Biotechnology (DBT), Government of India, grant number BT/PR19924/BIC/101/568/2016.
Publisher Copyright:
© 2021, The International CCN Society.
PY - 2021/12
Y1 - 2021/12
N2 - Severe acute respiratory syndrome coronaviruses (SARS-CoVs) caused worldwide epidemics over the past few decades. Extensive studies on various strains of coronaviruses provided a basic understanding of the pathogenesis of the disease. Presently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is leading a global pandemic with unprecedented challenges. This is the third coronavirus outbreak of this century. A signaling pathway map of signaling events induced by SARS-CoV infection is not yet available. In this study, we present a literature-annotated signaling pathway map of reactions induced by SARS-CoV infected cells. Multiple signaling modules were found to be orchestrated including PI3K-AKT, Ras-MAPK, JAK-STAT, Type 1 IFN and NFκB. The signaling pathway map of SARS-CoV consists of 110 molecules and 101 reactions mediated by SARS-CoV proteins. The pathway reaction data are available in various community standard data exchange formats including Systems Biology Graphical Notation (SBGN). The pathway map is publicly available through the GitHub repository and data in various formats can be freely downloadable.
AB - Severe acute respiratory syndrome coronaviruses (SARS-CoVs) caused worldwide epidemics over the past few decades. Extensive studies on various strains of coronaviruses provided a basic understanding of the pathogenesis of the disease. Presently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is leading a global pandemic with unprecedented challenges. This is the third coronavirus outbreak of this century. A signaling pathway map of signaling events induced by SARS-CoV infection is not yet available. In this study, we present a literature-annotated signaling pathway map of reactions induced by SARS-CoV infected cells. Multiple signaling modules were found to be orchestrated including PI3K-AKT, Ras-MAPK, JAK-STAT, Type 1 IFN and NFκB. The signaling pathway map of SARS-CoV consists of 110 molecules and 101 reactions mediated by SARS-CoV proteins. The pathway reaction data are available in various community standard data exchange formats including Systems Biology Graphical Notation (SBGN). The pathway map is publicly available through the GitHub repository and data in various formats can be freely downloadable.
KW - COVID-19
KW - Differential expression
KW - Post-translational modifications
KW - Protein–protein interaction
KW - Translocation
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U2 - 10.1007/s12079-021-00642-2
DO - 10.1007/s12079-021-00642-2
M3 - Article
AN - SCOPUS:85114468473
SN - 1873-9601
VL - 15
SP - 595
EP - 600
JO - Journal of Cell Communication and Signaling
JF - Journal of Cell Communication and Signaling
IS - 4
ER -