A Novel Wearable Device for Continuous Temperature Monitoring Fever Detection

Nishant Verma, Iman Haji-Abolhassani, Suhas Ganesh, Jesus Vera-Aguilera, Jonas Paludo, Roxana Heitz, Svetomir N. Markovic, Kimary Kulig, Atiyeh Ghoreyshi

Research output: Contribution to journalArticlepeer-review


Objective: Continuous temperature monitoring in high-risk patients can enable healthcare providers to remotely track patients' temperatures, promptly detect fevers and timely intervene to improve clinical outcomes. We evaluated if a novel wearable, continuous temperature monitor (Verily Patch) can reliably estimate body temperature and early detect fevers in an outpatient setting in patients at a high risk of febrile neutropenia (FN) who recently underwent chemotherapy and autologous stem cell transplantation (ASCT). Methods: 86 patients at a high risk for FN were prospectively enrolled at Mayo Clinic, MN. Patients wore the device in their axilla region for 7 days post ASCT and recorded self-measured oral temperatures every 3 hours. Patients were also followed using clinical standard-of-care procedures with daily oral temperature assessment. The clinic-and patient-assessed oral temperatures were used to develop and evaluate Verily Patch's body temperature and early fever detection algorithms using a K-fold cross-validation approach. Results: The Verily Patch reliably measured body temperatures with an error of 0.35 ± 0.88°F in comparison to clinic-and patient-assessed oral temperatures. The sensitivity and specificity of the patch in detecting clinic-assessed fever episodes was 90.2% and 87.8%. The patch detected 14.3 times the number of clinic-assessed fever episodes with a median lead time of 4.3 hours. Conclusion: Patient self-monitoring of temperature and fever incidents suffers from low accuracy and is impractical for extended periods of time. Continuous temperature monitoring by a wearable device (such as Verily Patch) has the potential to overcome these challenges resulting in better patient clinical outcomes and more cost-effective care.

Original languageEnglish (US)
Article number9490248
JournalIEEE Journal of Translational Engineering in Health and Medicine
StatePublished - 2021


  • Continuous temperature monitoring
  • early fever detection
  • febrile neutropenia
  • machine learning
  • wearable devices

ASJC Scopus subject areas

  • Biomedical Engineering


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