A Novel USP25::PDGFRA Gene Fusion in a 78 Year Old Patient with a Myeloid Neoplasm

Joanna C. Dalland; Patrick R. Blackburn; Kaaren K. Reichard; Sarah H. Johnson; James B. Smadbeck; George Vasmatzis; Nicole L. Hoppman; Xinjie Xu; Patricia T. Greipp; Linda B. Baughn; Jess F. Peterson

doi:10.1093/labmed/lmac010

A Novel USP25::PDGFRA Gene Fusion in a 78 Year Old Patient with a Myeloid Neoplasm

Joanna C. Dalland, Patrick R. Blackburn, Kaaren K. Reichard, Sarah H. Johnson, James B. Smadbeck, George Vasmatzis, Nicole L. Hoppman, Xinjie Xu, Patricia T. Greipp, Linda B. Baughn, Jess F. Peterson

Research output: Contribution to journal › Article › peer-review

Abstract

The World Health Organization category of myeloid/lymphoid neoplasms with eosinophilia and PDGFRA rearrangements is composed of a heterogeneous group of neoplasms that can present as a myeloproliferative neoplasm, acute myeloid leukemia, myeloid sarcoma, or lymphoblastic leukemia/lymphoma. The overall outcome of these neoplasms is favorable with imatinib therapy. Herein, we describe an adult female patient with a myeloid neoplasm accompanied by eosinophilia and a novel USP25::PDGFRA gene fusion.

Original language	English (US)
Pages (from-to)	E134-E138
Journal	Laboratory Medicine
Volume	53
Issue number	5
DOIs	https://doi.org/10.1093/labmed/lmac010
State	Published - Sep 1 2022

Keywords

PDGFRA
USP25
eosinophilia
mate-pair sequencing
next-generation sequencing

ASJC Scopus subject areas

Medicine(all)

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10.1093/labmed/lmac010

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title = "A Novel USP25::PDGFRA Gene Fusion in a 78 Year Old Patient with a Myeloid Neoplasm",

abstract = "The World Health Organization category of myeloid/lymphoid neoplasms with eosinophilia and PDGFRA rearrangements is composed of a heterogeneous group of neoplasms that can present as a myeloproliferative neoplasm, acute myeloid leukemia, myeloid sarcoma, or lymphoblastic leukemia/lymphoma. The overall outcome of these neoplasms is favorable with imatinib therapy. Herein, we describe an adult female patient with a myeloid neoplasm accompanied by eosinophilia and a novel USP25::PDGFRA gene fusion.",

keywords = "PDGFRA, USP25, eosinophilia, mate-pair sequencing, next-generation sequencing",

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AU - Dalland, Joanna C.

AU - Blackburn, Patrick R.

AU - Reichard, Kaaren K.

AU - Johnson, Sarah H.

AU - Smadbeck, James B.

AU - Vasmatzis, George

AU - Hoppman, Nicole L.

AU - Xu, Xinjie

AU - Greipp, Patricia T.

AU - Baughn, Linda B.

AU - Peterson, Jess F.

PY - 2022/9/1

Y1 - 2022/9/1

N2 - The World Health Organization category of myeloid/lymphoid neoplasms with eosinophilia and PDGFRA rearrangements is composed of a heterogeneous group of neoplasms that can present as a myeloproliferative neoplasm, acute myeloid leukemia, myeloid sarcoma, or lymphoblastic leukemia/lymphoma. The overall outcome of these neoplasms is favorable with imatinib therapy. Herein, we describe an adult female patient with a myeloid neoplasm accompanied by eosinophilia and a novel USP25::PDGFRA gene fusion.

AB - The World Health Organization category of myeloid/lymphoid neoplasms with eosinophilia and PDGFRA rearrangements is composed of a heterogeneous group of neoplasms that can present as a myeloproliferative neoplasm, acute myeloid leukemia, myeloid sarcoma, or lymphoblastic leukemia/lymphoma. The overall outcome of these neoplasms is favorable with imatinib therapy. Herein, we describe an adult female patient with a myeloid neoplasm accompanied by eosinophilia and a novel USP25::PDGFRA gene fusion.

KW - PDGFRA

KW - USP25

KW - eosinophilia

KW - mate-pair sequencing

KW - next-generation sequencing

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A Novel USP25::PDGFRA Gene Fusion in a 78 Year Old Patient with a Myeloid Neoplasm

Abstract

Keywords

ASJC Scopus subject areas

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