A novel tau mutation in exon 9 (1260V) causes a four-repeat tauopathy

Andrew Grover, Elisabet England, Mathew Baker, Naruhiko Sahara, Jennifer Adamson, Brian Granger, Henry Houlden, Ulla Passant, Shu Hui Yen, Michael DeTure, Michael Hutton

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


A novel mutation in exon 9 of tau, I260V, is associated with a clinical syndrome consistent with frontotemporal dementia with extensive tau pathology; however, neurofibrillary tangles and Pick bodies are absent. Significantly, Sarkosyl-insoluble tau extracted from affected brain tissue consisted almost exclusively of four-repeat isoforms. Consistent with these findings, in vitro biochemical assays demonstrated that the I260V mutation causes a selective increase in tau aggregation and a decrease in tau-induced microtubule assembly with four-repeat isoforms only. The contrasting pathology and biochemical effects of this mutation suggest a different disease mechanism from the other exon 9 mutations and demonstrates the critical role for the first microtubule-binding domain in tau-promoted microtubule assembly and the pathogenic aggregation of tau.

Original languageEnglish (US)
Pages (from-to)131-140
Number of pages10
JournalExperimental Neurology
Issue number1
StatePublished - Nov 2003


  • Aggregation
  • Axonal
  • Dementia
  • Four-repeat
  • Glial tau
  • Isoform
  • Microtubule assembly
  • Neurodegeneration
  • Pick body
  • Tau

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


Dive into the research topics of 'A novel tau mutation in exon 9 (1260V) causes a four-repeat tauopathy'. Together they form a unique fingerprint.

Cite this