A novel synthetic 1,3-phenyl bis-thiourea compound targets microtubule polymerization to cause cancer cell death

Keyphrases

• Microtubules 100%
• Cancer Cell Death 100%
• Phenyl 100%
• Microtubule Polymerization 100%
• Compound Target 100%
• Bisthiourea 100%
• Thiourea Compound 100%
• Drug Resistance 50%
• Overexpression 50%
• Apoptosis 50%
• Tubulin 50%
• Small Molecules 50%
• Cell Death 50%
• Dissociation 50%
• Cancer Cell Survival 50%
• Glioblastoma multiforme 50%
• Multiple Cancers 50%
• Cancer Cell Lines 50%
• Anticancer Therapy 50%
• Antitumor Effect 50%
• Mitosis 50%
• Cancer Chemotherapy 50%
• Therapy Development 50%
• Xenograft Mice 50%
• New Leads 50%
• Chemotherapeutic Target 50%
• P-glycoprotein (P-gp) 50%
• Thiourea 50%
• Nanomolar Concentrations 50%
• Cyclin B1 50%
• Prometaphase 50%
• Phenylene 50%
• Mitotic Arrest 50%
• Cytoskeletal Components 50%
• Spindle Abnormalities 50%
• Tubulin mutations 50%
• Prometaphase Arrest 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Malignant Neoplasm 100%
• Thiourea 100%
• Tubulin 66%
• Cancer Chemotherapy 33%
• Drug Resistance 33%
• Glioblastoma 33%
• Multiple Cancer 33%
• Lead Compound 33%
• Nude Mouse 33%
• P-Glycoprotein 33%
• Cyclin B1 33%