A Novel Approach to Essential Thrombocythemia and Cardiac Surgery

Bradford B. Smith, Gregory A. Nuttall, Rajiv K. Pruthi, David L. Joyce, Matthew S. Schuldes, Mark M. Smith

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Essential thrombocythemia (ET) is a myeloproliferative disorder characterized by persistent thrombocytosis (>450 × 109/L). Patients with ET are at risk for thrombotic or hemorrhagic complications especially during cardiovascular operations. We discuss a patient with ET requiring coronary artery bypass grafting with a presenting platelet count of 1631 × 109/L. Platelet reduction with an intraoperative autologous transfusion technique decreased the platelet count to 758 × 109/L before initiation of cardiopulmonary bypass. In addition, perioperative cangrelor therapy was administered to further limit risk of thrombotic complications. The patient had an uneventful perioperative and postoperative course.

Original languageEnglish (US)
Pages (from-to)e249-e250
JournalAnnals of Thoracic Surgery
Issue number3
StatePublished - Mar 1 2017

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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