A neuropsychological study of panic disorder: Negative findings

Julie Akiko Gladsjo, Mark Hyman Rapaport, Rebecca McKinney, John A. Lucas, Anthony Rabin, Tod Oliver, Jeffrey Davis, Michelle Auerbach, Lewis L. Judd

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Background: Gray (1982) proposed that the septo-hippocampal system, which plays an important role in learning and memory, may partially mediate anxiety. Thus, patients with anxiety disorders may manifest neurocognitive performance deficits. We hypothesized that patients with panic disorder would demonstrate learning and memory deficits relative to normal comparison subjects. Method: Comprehensive neuropsychological batteries were administered to 69 panic disorder subjects and 19 normal volunteers. Results: There were no significant group differences in any neuropsychological performance domain including learning, memory, attention, visuospatial functioning, and psychomotor speed. Multiple regression conducted to evaluate the contribution of clinical symptoms to neuropsychological impairment within the panic disorder sample revealed that anxiety severity did not affect neuropsychological test performance. Limitations: Most patients had mild or moderate, rather than severe, panic disorder. Conclusion: Neuropsychological dysfunction was not associated with panic disorder.

Original languageEnglish (US)
Pages (from-to)123-131
Number of pages9
JournalJournal of Affective Disorders
Issue number2
StatePublished - May 1998


  • Anxiety
  • Neuropsychology
  • Panic disorder

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


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