Abstract
Introduction. 4′-Iodo-4′-deoxydoxorubicin (IDOX) has been reported to bind to and lead to the catabolism of amyloid deposits. A multicenter study attempted to develop a dosing schedule to confirm those results. Methods. Patients with biopsy-proven amyloidosis were required to have a cardiac ejection fraction > 50%, ventricular septal thickness < 20 mm, serum creatinine < 2.5 mg per dL, bilirubin ≤ 2.0 mg per dL, neutrophils < 1,500 per μL, and platelets > 100,000 per μL. IDOX was administered intravenously over 1 hour at a dose of 15 mg per m2 once a week for 4 consecutive weeks. This therapy was repeated every 3 months up to 4 times. Results. Twenty-five previously treated and 15 untreated patients with primary amyloidosis (AL) received therapy. Fifteen patients had > 3 g of protein per day in the urine. Eleven patients had an ejection fraction < 60%. One, 2, 3, 4, and 5 organ systems were involved in 22, 10, 4, 3, and 1 patient, respectively. The median time between diagnosis and initiation of IDOX was 17.4 months. There were 6 responses (15%). Twelve of the patients have died. Conclusion. IDOX administered in this protocol was insufficiently active at the current dose.
Original language | English (US) |
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Pages (from-to) | 24-30 |
Number of pages | 7 |
Journal | Amyloid |
Volume | 9 |
Issue number | 1 |
DOIs | |
State | Published - 2002 |
Keywords
- Amyloid
- Amyloidosis
- Anthracycline
- Cardiomyopathy
- Chemotherapy
- Nephrotic syndrome
ASJC Scopus subject areas
- Internal Medicine